READER RESOURCES: THE APOCALYPSE ALMANAC: Hidden cures in our dystopian age. Check out the “Cure Cancer in Your Kitchen” chapter. FULLSCRIPT SUPPLEMENTS: top quality and economical.
Yoho Introduction
A Midwestern Doctor (AMD) has continued their phenomenal multi-volume series on DMSO with a book-length (53,000 words!) essay on neurology that compiles roughly 2,000 studies and 200 reader testimonials. The original was so long it crashed Substack and had to be shipped in two parts. Part one covered cellular mechanisms, safety, the circulatory model of neurodegeneration, and the named neurodegenerative diseases. Part two added myasthenia gravis, hydrocephalus, psychiatric conditions, sleep, Down Syndrome, sourcing, and dosing protocols.
This is too much for many readers, so I summarized it for you. I encourage you to save the brilliant original linked in the references and read it if you have time.
My other DMSO posts with their links:
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390. DMSO TRANSFORMS EYE TREATMENT another summary of AMD’s work.
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388. DMSO MADE ME STINK SO BAD THAT MY WIFE KICKED ME OUT OF THE HOUSE
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337. DMSO (dimethylsulfoxide) IS SECOND ONLY TO CHLORINE DIOXIDE FOR HEALING DISEASE
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307. DMSO IS A HARMLESS NATURAL WONDER DRUG WITH JUST ONE SIDE EFFECT–BAD BREATH
How to read this
My intent is not to confuse or discourage you with technical data. I want you to quickly scan this essay to understand the depth of scientific support for DMSO. It is my opinion, and probably the opinion of AMD, that DMSO has more supporting studies than any pharma drug. It was so effective for so many diseases that there was a vast wave of enthusiasm for it, but it was squashed by congressional action that almost took it off the market.
My readers realize that corruption like this is a common pattern, but if you are here for the first time, it is shocking. The background history is in the posts linked above.
This essay was written by me using the voice of A Midwestern Doctor, and the inevitable mistakes and misinterpretations are all mine.
Summary
• DMSO scavenges hydroxyl radicals, raises cerebral blood flow, opens the blood-brain barrier (BBB) reversibly, stabilizes misfolded proteins, and clears the blood sludging that obstructs cerebral microcirculation.
• A young-onset Parkinson’s disease (PD) case-control study found DMSO exposure linked to a 10-fold reduction in risk, while insecticides raised risk nearly 6-fold and herbicides over 3-fold.
• Direct or combination evidence supports DMSO in Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Huntington’s, multiple sclerosis (MS), prion disease, Niemann-Pick C, myasthenia gravis (MG), hydrocephalus, epilepsy, depression, and schizophrenia.
• Down Syndrome trials in Oregon, Chile, and Argentina showed dose-dependent gains in IQ, motor scores, language, and social function. Three documented children, Melody Clark, Bronwyn Nash, and Billy King, moved from severe disability to near-normal cognition on long-term DMSO with amino acids.
• Reader reports document brain fog clearing, restless leg syndrome resolving, dementia patients speaking again, ALS halted, post-stroke speech and feeding restored, MS trigeminal neuralgia dropping 99 percent, and lucid dreams of unusual vividness.
• AMD’s framework treats most chronic neurological disease as a downstream consequence of impaired cerebral microcirculation. DMSO addresses that root cause.
Cellular protection
DMSO protects cells from stressors that ought to kill them. It made cryopreservation possible by preventing freezing damage, and it has saved fingers, ears, and limbs from frostbite in animals and humans. In hippocampal slices, DMSO neutralized oxidative stress. In cerebellar granule neurons, it prevented apoptosis caused by glutamate toxicity, restoring 66 to 76 percent of normal electrical activity. In rat brain homogenates, it cut hydroxyl radical-induced lipid peroxidation and protein carbonyl formation.
It also blocks damage from chemotherapeutics (cyclophosphamide, cisplatin, doxorubicin, the last with curcumin to prevent “chemobrain”), heavy metals (lead, aluminum, mercury, manganese, cadmium, lithium, arsenic, fluoride), organophosphates including nerve gas, snake venom, and radiation up to lethal doses in mice, rabbits, dogs, and monkeys. In two horses swarmed by African bees, IV DMSO reversed severe neurological impairment within 5 hours. In a comatose dog given a toxic dose of ivermectin paste, IV DMSO restored full neurological function.
Safety
DMSO has an unusually wide therapeutic window. The known issues are skin itching at high topical doses, the sulfur odor some users develop, an allergy in roughly 1 in 2,000, transport of skin contaminants into the body if not washed off after application, potentiation of alcohol and barbiturates, and osmotic hemolysis at high IV doses. Almost every reported severe adverse event from IV DMSO traces to one of three causes: embolic agents administered alongside it, fragile post-chemotherapy cancer patients given high doses, or phthalates leached from IV tubing.
DMSO crosses the skin and enters the bloodstream within 5 minutes, reaches the organs within 30 minutes, and reaches the bones within an hour. It does not accumulate. 85 percent leaves unchanged in urine within 24 hours. Almost none is left a week after administration.
The circulatory model of disease
In the 1940s and 1960s, Melvin Knisely showed that “blood sludging,” red cells clumping together, drove much of what hospitalized patients. He saw it in burns, malaria, and cancer. Thomas Riddick, an industrial chemist who used colloidal dispersion daily, cured his “incurable” heart disease by treating his blood the way he treated industrial colloids: by raising its zeta potential, the electrical repulsion that keeps suspended particles apart. He concluded that aluminum was the most dangerous ion in human biology because of its strong positive charge.
Canadian neurologist Andrew Moulden saw children develop signs of microstrokes after vaccination. He attributed this to aluminum and other zeta-potential-disrupting agents in vaccines, which clump blood cells in cerebral microcirculation, with larger inflammatory white cells then obstructing what flow remains. The damage was too small to show on imaging, which is one reason chronic neurological disease so rarely yields a clean diagnosis.
DMSO does not directly raise red cell zeta potential. What it does is stabilize the gels that keep blood cells dispersed, neutralize the aggregating proteins Knisely identified, and counteract pathologic clumping factors. In a 2009 study in Georgia, heating rat cerebrospinal fluid induced microclotting, loss of cerebral blood flow, and tissue damage; DMSO blocked all three. In rat lymphatic vessels, DMSO doubled the rate of phasic contractions, doubled lymph velocity, and removed staphylococcal toxins’ lymphoconstrictive effect.
Crossing the blood-brain barrier
At concentrations of 10 to 15 percent, DMSO reversibly opens the BBB. This delivers proteins such as horseradish peroxidase, drugs including ketoconazole (brain concentrations up to 9-fold) and L-dopa (with carbidopa), drug-carrying lysosomes, and amino acids to brain tissue at levels they would not otherwise reach. In neonatal chicks, IV DMSO raised brain adrenaline and noradrenaline by 35 to 39 percent. In dogs, CSF DMSO concentrations were half those in plasma. DMSO has been grouped with mannitol as a clinical agent for enhancing brain drug delivery.
A Russian theory of psychiatric disease
The Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences produced what I consider the strongest mechanistic case for circulatory dysfunction underlying psychiatric illness. They induced “neurosis” in animals through three weeks of white noise, light flashes, and electric shocks, then measured cerebral blood flow with biomicroscopy and hydrogen clearance, then dissected the brains.
Chronic stress reduces cerebral blood flow from a normal 50 to below 30 ml per 100 grams per minute, a state that persists for 4 to 6 weeks after the stressor ends. Hypoxia increases lactate, depresses caspase-3 and Na/K-ATPase, impairs mitochondrial respiration, and triggers reactive oxygen species and lipid peroxidation. Cerebral autoregulation breaks down. Hippocampal CA3 cells shrivel; CA1 loses 2.7 to 7.1 percent of its cells, near the threshold for cognitive impairment and dementia.
They tested a long list of agents. The combination that worked best was oral DMSO at 50 mg/kg with vitamin E at 5 mg/kg. The DMSO delivered vitamin E to cell membranes before other reactions in the body neutralized it. The combination raised brain phospholipid content, normalized cholesterol, and ran in government-sanctioned trials at the Moscow Medical Academy by 1999.
Parkinson’s disease
Parkinson’s disease results from progressive loss of dopamine-producing neurons in the substantia nigra. The MPTP-contaminated synthetic heroin episode of the early 1980s revealed that the active metabolite MPP+ targets these neurons, opening the door to reliable animal models. Paraquat is structurally similar to MPP+. Rotenone, organophosphates, and 6-OHDA all produce comparable damage. The herbicides glyphosate replaced are more neurotoxic than glyphosate itself.
A young-onset Parkinson’s case-control study (63 cases, 68 controls) found people with PD were one-tenth as likely to have been exposed to DMSO as healthy controls, a 10-fold inverse association. The same study found insecticide exposure raised risk nearly 6-fold, fumigated housing over 5-fold, and herbicides over 3-fold. Smoking dropped PD risk, consistent with decades of nicotine epidemiology.
DMSO’s mechanisms in PD are direct. In animals, it suppresses hydroxyl radical-induced nigrostriatal injury from MPTP. In rotenone-induced PD rats, DMSO restored hippocampal CA1 and CA3 morphology, with pyramidal cells and Nissl bodies recovering and electrical activity normalizing. DMSO protected astrocytes from MPP+ toxicity, glial glutamine synthetase from MPP+-induced hydroxyl damage, and human SH-SY5Y neuroblastoma cells from 6-OHDA cytotoxicity. It blocked rotenone’s complete blockade of microtubule assembly from purified tubulin, a finding with direct relevance to PD, since axonal transport depends on intact microtubules.
DMS, DMSO’s odor-producing metabolite, also protected neurons against 6-OHDA and MPP+ apoptosis at near-physiological concentrations. The effect depended on MsrA, the enzyme that converts DMS to DMSO, suggesting an endogenous DMS-DMSO cycle as part of the body’s antioxidant defense against dopaminergic neurodegeneration. This raises a clinical conundrum: some PD patients respond dramatically to DMSO but quit because of the odor, and a low-odor formulation might lose part of the therapeutic effect.
Combination studies show a wide reach. Curcumin protected nigral dopaminergic neurons. Paeoniflorin reduced α-synuclein expression and Lewy body formation. Icariside II differentiated mesenchymal stem cells into dopaminergic neuron-like cells. Ginsenosides Rg1 and Rg3, geniposide, ginkgolide B, ambroxol, polyphenols, and carnosic acid all attenuated dopaminergic loss or α-synuclein accumulation. L-sulforaphane in DMSO activated the NRF2 pathway in patient-derived cells, restoring deficient glutathione.
NAMI-A, a low-toxicity ruthenium-DMSO complex, inhibited α-synuclein aggregation, disassembled pre-formed fibrils, abolished cytotoxicity, and reduced motor impairments in rat PD models. In MPTP models, tanshinone IIA preserved roughly 75 percent of dopaminergic neurons. Tetramethylpyrazine prevented motor deficits via Nrf2. 6-Hydroxy-1H-indazole protected 90-93% of dopaminergic neurons. Baicalein modulates rotational behavior and dopaminergic apoptosis. NBP rescued dopaminergic neurons by 30 percent and striatal dopamine terminals by 49 percent.
Since paraquat and herbicides are among the strongest environmental risk factors for PD, it matters that DMSO scavenges up to 96 percent of the superoxide radicals paraquat generates. DMSO also intercepts paraquat’s hydroxyl radicals via Fenton-like chemistry in rats, protects striatal cells in culture, suppresses paraquat-induced inflammatory signaling, and blocks paraquat’s mutagenic DNA damage. This gives a mechanistic explanation for the 10-fold epidemiologic protection.
A caveat. One in vitro study found DMSO at 0.75 to 1.0 percent, combined with ferric iron, promoted α-synuclein oligomer formation. Oral DMSO in living mice (normal and α-synuclein transgenic) showed no aggregation, no neuronal loss, and no PD-like pathology. DMSO injected directly into the substantia nigra also did no damage. Whatever pro-aggregant effect DMSO has in cell culture at concentrations beyond those that reach the brain clinically does not translate to the living animal.
Reader and physician reports corroborate the experimental data. One PD patient on stem cell therapy in Amsterdam received an IV mannitol-DMSO drip. Within hours, he bounced down a flight of stairs without a handrail, cut his food for a week, opened cab doors, and his speech became fluent. Stem cells take months to act; this was the DMSO. A research scientist diagnosed with PD in 2018 had controlled non-motor symptoms with sulforaphane but kept the full motor symptoms. After systematic testing of oral DMSO, at his optimal dose, bradykinesia was eliminated, pain and dystonia dropped 80 percent, stiffness dropped 50 percent, and energy rose. Doses above his threshold worsened tremor, stiffness, and sleep, with full reversal in two days off.
Yoho comment: DMSO has serious potential for PD treatment. Oral helps. IV helps more. The best results will come from pairing DMSO with a complementary neurotrophic agent. The young-onset case-control finding alone, a 10-fold inverse association in a disease of accelerating prevalence, would in a less captured medical system prompt a national prevention campaign. Instead, it sits on a Substack.
Amyotrophic lateral sclerosis
In ALS model mice, long-term oral 5 percent DMSO treatment raised survival, lowered neurological scores, and improved motor performance. DMSO at low concentrations stabilized SOD1 conformation; SOD1 misfolding is a central cause of ALS. Resveratrol delayed the onset and preserved nearly twice as many motor neurons. Stanley Jacob produced “instant, overnight, and slightly delayed wonders of therapy” in an ALS patient before the patient’s doctor forbade further treatment. A reader with cramping fasciculation syndrome (an early-ALS-like condition) was suicidal from chronic pain and sleep deprivation before oral DMSO restored sleep, eliminated his pain, and gave him back his job. AMD’s experience: IV DMSO halts ALS progression rather than reverses it.
Huntington’s disease
Huntington’s belongs to a family of nine polyglutamine diseases caused by misfolded proteins with abnormally long glutamine repeats. A review of chemical chaperones found DMSO equal to or better than glycerol and TMAO at suppressing polyglutamine toxicity. In Machado-Joseph disease cell models, DMSO stabilized ataxin-3, cutting aggregation, cytotoxicity, and cell death. The only direct Huntington’s study showed that DMSO at 1 to 4 percent partially prevented cell death, increased viability, decreased aggregated huntingtin, and increased the soluble, non-toxic form.
Alzheimer’s disease
DMSO stabilizes proteins and dissolves misfolded amyloid aggregates. Computer modeling shows it inhibits Aβ aggregation by modulating the Lys28-Ala42 salt bridge. Molecular dynamics simulations show DMSO promotes α-helical structure and stabilizes Aβ42. DMSO inhibits acetylcholinesterase, a therapeutic strategy similar to that of donepezil and galantamine. It raises lysosomal alkaline phosphatase activity by 20 percent. It blocks NLRP3 inflammasome and caspase-1 activation, the mediators of chronic AD-driving neuroinflammation.
In rats with intracerebroventricular streptozotocin (a sporadic AD model), IV DMSO daily for two weeks reversed memory impairment. Chronic 10 percent intracerebroventricular DMSO attenuated spatial memory deficits in the Morris water maze. In transgenic AD mice, DMSO, region-specifically, raised spine density, improved spatial memory, and produced an anti-anxiety effect, all without reducing oligomeric Aβ. The authors concluded DMSO should be considered a true bioactive compound, not a vehicle.
Eighteen Alzheimer’s patients in Moldova on DMSO showed substantial gains in memory, concentration, communication, and time-and-space orientation by three months. Jack De La Torre, the leading researcher on DMSO’s neurological applications, wrote that DMSO improved cognitive function and stabilized protein enzymes in AD patients after six months of treatment.
Reader reports cluster around dementia and stroke recoveries. An uncle’s wife, mute for over a year, talked again after two weeks of oral DMSO. A 93-year-old with 15 years of dementia had her sundowning resolve and her personality return. A stroke patient regained speech, strength, eating, and use of his affected hand over eight weeks of oral DMSO with galactose. A 75-year-old with an inoperable 8 cm glioblastoma and a 3-week prognosis recovered motor function within 24 hours of topical 99 percent DMSO, walked with a walker by week 4, and on a day-55 CT scan showed no brain bleed and reduced tumor metrics.
Multiple sclerosis
DMSO crosses the BBB, dampens harmful immune activity, cuts inflammation, improves circulation to white matter, and stabilizes proteins. It also blocks the clotting that myelin debris triggers, a secondary mechanism of MS neurodegeneration that no current anticoagulant targets. The chronic cerebrospinal venous insufficiency (CCSVI) theory of MS holds that impaired jugular drainage, often due to chronic endothelial infections (Borrelia, Rickettsia, Chlamydia pneumoniae, Babesia), traps inflammatory toxins and pathological proteins. Dietrich Klinghardt found CCSVI in 100 percent of his MS, autism, Parkinson’s, ALS, and Lyme patients.
Stanley Jacob’s most famous case was a 29-year-old paralyzed from MS with kidney failure, given oral DMSO. “Her improvement was dramatic, as dramatic as any benefit I have ever seen,” he wrote. Six years later, she walked, drove, and cared for her family. A 1984 Russian study of 34 MS patients found broad benefit, with the greatest effect in remitting MS, with DMSO causing remyelination, reducing edema, improving nerve cell communication, and raising immunity. Reader reports include MS trigeminal neuralgia of 18 months dropping 99.9 percent in a day, MS hugs going to a standstill, and MS with fibromyalgia, liver fibrosis, complex regional pain syndrome, and lymphedema responding to oral and topical DMSO as “a godsend.”
Niemann-Pick C and prion disease
DMSO is one of the best-studied chemical chaperones. In Niemann-Pick C fibroblasts, 2 percent DMSO raised sphingomyelinase activity by 480 percent, correcting the deficiency. In NPC mice, oral DMSO doubled survival and delayed the onset of tremor. In a Japanese case of an 8-year-old girl with severe NPC psychomotor deterioration, frequent seizures, cortical atrophy, and hepatosplenomegaly, two years of oral DMSO normalized sphingomyelinase activity, decreased her seizures enough to taper her anticonvulsant, normalized her EEG theta waves and spindles, halted cortical atrophy, and shrank her spleen and liver to normal.
In prion disease, DMSO stabilized the alpha-helical structure of newly synthesized prion protein in infected neuroblastoma cells, blocking conversion to the pathogenic form. In yeast prion models, DMSO cured multiple variants better than guanidine hydrochloride. One reader’s cousin with CJD improved after a month of IV DMSO infusions and was alive years later.
Cognitive impairment, dementia, and memory
In rats with surgically reduced cerebral blood flow, DMSO blocked the neuronal damage and spatial memory loss that followed. In Lurcher mice (a model of cerebellar disorder), DMSO prevented age-related deterioration in memory and spatial learning. 104 elderly patients with cerebrovascular disease, head injury, senility, or degenerative disease (PD, hyperthyroidism, epilepsy) received Merinex (DMSO with amino acids) and Ipran (DMSO with vasoactive substances), with striking improvements. A Chilean study of 100 patients with cerebrovascular disease used oral and intramuscular DMSO over 50 days; coronary disease and hypertension improved well in 74.35 percent. In 127 patients aged 75 to 85 with cerebrovascular disorders, bitemporal Neuromidin-DMSO electrophoresis produced clinical improvement in 86% of patients by the fifth procedure.
For anesthesia-induced cognitive impairment, resveratrol with DMSO blocked sevoflurane-induced cognitive deficits in aged and neonatal rats via the SIRT1 pathway. Arctigenin, honokiol, SAHA, curcumin, and dexmedetomidine each protected against neurotoxicity induced by sevoflurane, propofol, isoflurane, etomidate, ropivacaine, and ketamine.
Reader reports include a series of small strokes resolved on 1 teaspoon oral DMSO twice daily, post-hip-replacement brain fog cleared in a week of 2 teaspoons in water, and a 3.5-year Moderna injury patient with gastroparesis, brain fog, edema, small fiber neuropathy, mast cell activation, postural orthostatic tachycardia, tinnitus, and insomnia improving for the first time.
Movement disorders, seizures, and epilepsy
DMSO’s anticonvulsant effects are biphasic. Low doses suppress seizures; high doses provoke them. Low-dose DMSO at 1.65 mg/kg cut seizures in genetically epileptic rats. High-dose DMSO at 1651 mg/kg prolonged seizure latency by 32 percent and shortened seizure duration by 34 percent in temporal lobe epilepsy via NMDA/AMPA suppression. In chronic temporal lobe epileptic mice, 100 percent DMSO cut seizure number and duration by 19 to 41 percent. Reader reports describe topical DMSO dramatically improving restless leg syndrome, essential tremor, vaccine-induced Stiff Person Syndrome (the only treatment that touched 22 months of muscle spasm), and vestibular episodes in dogs.
Encephalitis, MG, and hydrocephalus
DMSO has been used for viral encephalitis (West Nile, herpes, Japanese encephalitis), bacterial meningitis, sepsis-associated encephalopathy, and parasitic encephalitides. In equine leukoencephalomalacia from Fusarium mycotoxins, a DMSO regimen halved death rates from 66 to 33 percent.
For myasthenia gravis, DMSO drops anti-acetylcholine-receptor antibodies by 53 to 76 percent in rats, regardless of route. In tubocurarine-paralyzed nerve-muscle preparations, 0.75 percent DMSO restored complete twitch force for over 150 minutes. The 1980 New York Times covered the discovery, and the researchers were eager to test in humans. No human MG study has ever been done. One reader with generalized MG who started oral and topical DMSO in 2022 has had no myasthenic crisis since, with dramatically reduced muscle fatigue, restored cognition, and near-normal vision, better, she said, “than the pyridostigmine I used to take 6x/day.” Another reader with generalized MG and multiple autoimmune conditions came off nearly all 30 of her prescription medications.
For hydrocephalus, a Shih Tzu with severe acute neurological symptoms had its seizures suppressed and consciousness restored by IV 10 percent DMSO. One reader’s brother, with syringomyelia, cervical astrocytoma, paralysis, and hydrocephalus, given a fatal prognosis, instead lived 30 more years after Stanley Jacob put him on experimental DMSO.
Psychiatric conditions
In a 1967 Peruvian psychiatric trial, 42 patients (25 schizophrenics, 4 manic-depressives, 4 alcoholic psychotics, 4 obsessive-compulsives, 5 with severe anxiety) were taken off all medication and given 2 to 5 daily intramuscular DMSO injections. Of the 14 acute schizophrenics, all had rapid, dramatic improvement. All 14 were discharged within 45 days, three at full recovery within 15 days. Of 11 chronic schizophrenics, some hospitalized for over 6 years, 4 went into full remission. The 4 manic-depressives in the manic phase rapidly calmed and lost their mania. The 4 alcoholic psychotics responded within days. The OCD and anxiety patients calmed and stopped acting on their compulsions. The authors noted DMSO’s action differed from that of tranquilizers in that little sedation or central depression was produced.
In 17 patients with chronic depression of 5 to 20 years, refractory to antidepressants, oral DMSO with their existing antidepressant resolved 14 of 17 (82.3 percent), with the remission persisting through 1 to 4 years of follow-up. Two Chilean studies of depressive neuroses on DMSO with amino acids showed similar benefit.
For PTSD, stress, depression, and anxiety, dozens of natural compounds and pharmaceuticals delivered in DMSO showed benefit in rodent models. In one chronic emotional-painful stress study, DMSO alone before the stressor blocked gastric ulcers, prevented anxiety behaviors, normalized cardiovascular responses, and raised brain superoxide dismutase. Sedation at higher doses traces to DMSO’s parasympathetic effect via acetylcholinesterase inhibition, which also explains its psychiatric reach: excessive sympathetic tone drives anxiety, mania, and psychosis.
Sleep
DMSO is not a sleeping pill. In 6,000 reader reports, only a handful describe direct sedation. What DMSO does is treat the conditions that prevent sleep. Most often, this was musculoskeletal pain, including shoulder bursitis, low back pain, arthritis, knee pain, neck pain, jaw pain, peripheral neuropathy, headaches, restless leg syndrome, and trigeminal neuralgia. Reader after reader reported that dropping pain meant getting their first full night of sleep in years. Many also reported an unusual increase in dream vividness and lucid dreaming, plausibly from DMSO’s acetylcholinesterase inhibition, the same mechanism behind galantamine.
Down Syndrome and developmental disabilities
The Down Syndrome data is what nearly cost AMD their credibility, then the testimonials came in. In Oregon, 67 moderately or severely disabled children with Down Syndrome (4 to 17) were randomized to high or low DMSO and compared to 23 untreated controls; a dose-dependent improvement was observed with no side effects. In Chile, 55 children with severe Down Syndrome got DMSO with GABA, GABOB, and acetylglutamine by injection, and their Gesell scores rose markedly across motor, adaptive, language, and social domains. In Argentina, 13 disabled children on the same DMSO-amino-acid protocol over 180 days showed parallel gains.
Melody Clark started on DMSO at 11 months when her legs were “like a rag doll’s” and her eyes failed to focus, and she moved over seven years from “practically a vegetable state of existence” to mild developmental delay. She read phonetically, did math, jumped rope, did somersaults, played on a trampoline, used full sentences, and was popular with classmates. Her dentist testified that her palate, jaw, and tongue had returned to normal.
Bronwyn Nash, who started at 10 months while failing to gain weight, became alert, cheerful, and steadily improving by 28 months. Billy King, who at 14 had the cognitive function of a 10-month-old, was given oral DMSO daily and within two years had the function of a 7-year-old. He continued to improve, lost the characteristic features of Down Syndrome, and eventually held a job at a Portland bookstore.
A 1969 study of 44 severely delayed children on DMSO-amino acids showed over 70 percent had favorable responses, including IQ gains, accelerated reading, writing, and math, improved coordination, reduced behavioral problems, lessened anger, and better psychomotor control. A 1980 Congressional hearing convened to pressure the FDA to lift its DMSO embargo failed in that goal, but produced these testimonies on the record. The German DMSO community has refined the amino-acid-DMSO formulations and uses them for learning disabilities, developmental delays, mood and anxiety disorders, and neurodegenerative diseases.
Autism
The most frequent question AMD receives is whether DMSO helps autism. He has only vague second-hand parent reports, no direct human evidence to weigh. The mouse model data are substantial. In autism-modified mice, Epothilone D (a microtubule-stabilizing agent) improved repetitive behaviors, increased the number of excitatory synapses, and enhanced myelin basic protein expression in the cortex across multiple studies. Curcumin enhanced sociability, reduced repetitive behaviors, and restored hippocampal neurogenesis. Prenatal resveratrol blocked valproic-acid-induced autism features in offspring. Melatonin, in combination with the PI3K inhibitor Wortmannin, improved synapse-associated protein synthesis and dendritic spine development. A 5-HT2A receptor antagonist attenuated repetitive self-grooming. Estradiol restored empathy and social affection in ovariectomized mice. Baicalin dose-dependently improved recognition and spatial memory while raising BDNF in the hippocampus.
Almost all these studies used DMSO as the delivery vehicle without a saline placebo arm, so the design cannot prove DMSO’s independent contribution. AMD reads the consistent benefit across mechanistically diverse agents as suggestive that DMSO itself contributes.
Other developmental disorders
Cerebral palsy. Direct human data is sparse. DMSO with verteporfin partially restored muscle satellite cell differentiation in vitro. Veterinary literature reports DMSO treats neonatal hypoxic-ischemic encephalopathy in foals, and Jack Metcalf documented foals born too disabled to nurse regaining the ability after IV DMSO three times daily. Russian researchers patented an ultrasound-assisted topical mixture of DMSO, sodium oxybutyrate (GHB), and lidocaine for the treatment of severe spasticity associated with arachnoiditis, with the patent extending its use to poliomyelitis and cerebral palsy. One reader with a cognitively intact nine-year-old daughter who has cerebral palsy reported that topical DMSO relaxed her tight muscles enough to improve mobility.
Cleft palate. DMSO prevented phenytoin-induced cleft palate in animal models. Phenytoin causes a constellation of birth defects (flat nasal bridge, epicanthal folds) that resemble features of Down Syndrome.
ACBD6-related neurodevelopmental syndrome. This rare disease produces cognitive impairment and Down-Syndrome-like birth defects from defective N-myristoyltransferase activity. DMSO has been shown in vitro to upregulate that same enzyme.
Krabbe disease. Stanley Jacob developed an oral DMSO protocol for this lysosomal storage disease that causes severe early-life neurodegeneration. The clinical outcome was not formally published.
Tourette syndrome. In disease-model rats, vitamin D in DMSO at 1.0 μg/kg/day decreased locomotor scores from 0.92 to 1.33, down to 0.43 to 0.69, and reversed the striatal dopamine deficit.
Muscular dystrophy. Epicatechin in DMSO reduced dystrophic fiber pathology and promoted muscle regeneration in MD mice, but did not address the underlying disease mechanism.
A new model of neurology
AMD’s framework: many “incurable” neurological diseases are downstream of impaired cerebral and lymphatic microcirculation. Once circulation drops, neurons trapped in a dormant penumbra state never wake. DMSO clears the sludging, opens the BBB, scavenges hydroxyls, stabilizes misfolded proteins, drains lymphatics, and resets the autonomic balance. The therapy is cheap, off-patent, broadly applicable, and competes with branded products that bring in billions, which is why it stays buried.
AMD has also flagged that the original article was split into multiple parts. Forthcoming pieces will cover spinal injuries (paralysis, cord injuries, disc disease, radiculopathies, arachnoiditis), peripheral nerve conditions (regeneration, palsies, neuropathies, neuropathic pain), and acute cerebrovascular events (strokes, brain bleeds, traumatic brain injuries, concussions). The current article closes with practical guidance: how to source pharmaceutical-grade DMSO, dosing by route and concentration, IV protocols, and condition-specific regimens for Parkinson’s, Alzheimer’s, strokes, anesthesia toxicity, brain fog, chronic stress, and developmental disorders.
Yoho comment:
AMD’s practical-guidance section is behind a Substack paywall. Their work merits the subscription, and reproducing their protocols here would be unethical. What follows are my observations on DMSO therapeutic dosing, drawn from my experience.
The critical part of all decisions is to sort truth from nonsense. With any source, even AMD, you must repeat the analysis yourself.
We live in a time when the cost of intravenous DMSO has purposefully been rendered outrageous, and its accessibility is behind a wall of corrupt licensure. I find it hard, from a mechanistic standpoint, to see how intravenous DMSO is any better than oral DMSO, which is immediately absorbed into every part of the body. I know you will remind me that I am known for worshiping empiricism at the expense of mechanism, and that AMD’s document is built around case reports. You are right.
The following is my current approach to DMSO dosing. If you want the entire literature examination, go past the paywall and read the thrilling conclusion of AMD’s book.
DMSO is a non-toxic tree product that produces remarkable anti-inflammatory and other beneficial effects on health. An early study gave a group of convicts a cup of it every day for three months, and they were none the worse for wear.
I increased my consumption after reading AMD’s article. I have recently gotten to the point where I don’t even measure what I take carefully. Instead, I pour an inch of full-strength DMSO in the bottom of a 12-oz glass water bottle, then fill it to the top and drink it throughout the day. This is about ten tablespoons. I have not seen side effects to date.
My use of high doses is a short-term experiment and unknown territory. Since paradoxical negative effects of DMSO have been observed at higher doses, I recommend that you analyze this and decide on your dose yourself. The smart approach is to start low and go slow. A teaspoon to three tablespoons in water or juice is more prudent than my methods.
I buy all my DMSO in gallon plastic bottles from DMSOstore.com on Amazon and dilute it as needed, depending on the purpose. They also sell it in glass bottles, but I assume that the people who sell the most DMSO have the sense to use a plastic that doesn’t dissolve it.
To treat my macular degeneration, I look into a red light daily and put 50% DMSO on my palm and then on the outside of my eyelids several times a day. This penetrates the retina, corrects my dry eyes, destroys floaters, and has other beneficial effects. Eye drops are also an option, but unless you dilute them heavily, they sting. The sting does no harm, but it is irritating. For more about that, see my summary of AMD’s eye/DMSO post linked in the introductory paragraph of this essay. My original post about how I was treating my macular degeneration is A DRAMA IN FOUR ACTS: MY AGE-RELATED MACULAR DEGENERATION.
Topical DMSO is not complicated. It sometimes produces skin irritation, but generally, all you have to do if that happens is dilute the stuff further. Everyone is different; you have to experiment.
Selected references
“How DMSO Heals the Brain and Transforms Neurology” (Part 1) by A Midwestern Doctor, The Forgotten Side of Medicine, 2026.
“DMSO and Neurology Part 2”, A Midwestern Doctor.
“Forgotten Discoveries About Resolving the Root Causes of Disease (Zeta Potential)”, A Midwestern Doctor.
Stanley Jacob, MD on DMSO and the 1980 Congressional hearings, historical archive.
Stanley Jacob, MD, on DMSO and the 1980 Congressional Hearings
The cleanest replacement is the original primary-source PDF:
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https://irp-cdn.multiscreensite.com/73bf25b2/files/uploaded/dmso-the-persecuted-drug-cm.pdf(Pat McGrady’s The Persecuted Drug — The Story of DMSO, the 1973 book that documents the FDA suppression and Jacob’s Senate testimony) -
Alternatively, the Washington Post archive coverage:
https://www.washingtonpost.com/archive/politics/1980/08/01/fda-aides-probed-in-testing-of-dmso-miracle-medicine/4a1c5e35-213e-4167-ad24-b60ab94cb28e/
The McGrady PDF is the better link — it’s the primary historical document, hosts on a stable CDN, and gives the reader the full story. The Washington Post archive is a good backup if you prefer mainstream-source corroboration.
Andrew Moulden, M.D., P.H.D., on vaccine micro-strokes:
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https://archive.org/details/every-vaccine-produces-harm-dr-andrew-moulden(the Internet Archive ebook of Dr. Andrew Moulden: Every Vaccine Produces Harm) -
Or the Lies are Unbekoming Substack profile:
Disclaimer: This is not medical advice and is not a substitute for your study and judgment. Use a knowledgeable provider if you can find one, but buying DMSO from DMSOSTORE.COM is a good first step and better than doing nothing. It safely improves everything from back pain to macular degeneration to Parkinson’s to many other entities.
Affiliate store: I will never use paywalls, but if you want to help me, I offer competitively priced affiliate products HERE that I have personally tested and used. There is a new entry for grass-fed beef.
Special note:
I get so many emails that I can’t answer them all. Please help me out on this one and use the comment section instead.
Do you think I could give DMSO to someone on a glp1?
Anyone know?
Do you think it would help a narcissist ? A real bad one?
Personality disorders (unlike psychiatric illnesses) are classicly considered to be untreatable, and in the DMSO literature, while psychiatric illnesses responded to it, personality disorders were never tested.
That said, I have seen a few cases of people who were very self centered and not nice to others who then became much kinder and caring about the world are the circulatory issues in their brain were addressed.
PTL!
A big thanks to AMD for the heavy lifting details found in a massive series covering DMSO. My health, family, and acquaintances have been improved due to this knowledge.
Thanks to Dr. Yoho for his work sharing his health journey and summarizing/supporting AMDu2019s work.
Now off to update my new trialsu2026
Haha let’s put it in congress water? Thanks , maybe a testing is in order?
Replace Fluoride with DMSO! Ha
The Moulden and Jacob articles links did not work. How to get them?
I fixed it. Sorry about that.
I’d be selling a house to get iv DMSO if that other persons reported experience was a regular response in all people taking IV DMSO that way. Unfortunately it’s not.
Again, these studies not done by you have ignored mthfr variant humans as their response will be different to DMSO.
They have also ignored that metals go through the BBB easily and that the cause of epilepsy has been discovered to be aluminium due to an industrial accident in the UK. All the exposed survivors got epilepsy.
Alum was put in the wrong place at the water treatment plant, resulting in high levels being ingested. It was Camelford I think.
Children in high pollution areas are also getting the symptoms of Parkinson’s and Alzheimer’s. No kids in low pollution areas found.
The metals from pollution were found in their brain stem.
My blood smear showed red blood cells clumping together. They had lost their electrical charge and didn’t look like red blood cells anymore. They weren’t round at all. They were all dented like they’d been in a pile up. No natural killer t cells could be found either. My blood hardly moved at all. The specialist said he regularly sees patients referred from oncologists, but he had never seen blood that looked that bad. I really should get it done again as I’m better, so surely it’s improved.
What do you attribute your (former, thank God) condition to?
There was an accident in surgery. A hole was accidentally drilled into my spine which started gushing out with blood. They surgeon used bone cement to plug the hole, but now I have a blob of bone cement amongst the blood stream in my spine.
The way I reversed the symptoms, was to simply remove as many foreign objects from the body that I could, as the bone cement couldn’t be removed. I also had to flush all the vitamin c fromy body to hobble my detox system.
My composite dental fillings were replaced with metal salt free ceramics and that stopped the symptoms of metal intoxication and cardiac symptoms immediately. It broughth pulse back down to its normal 60 from 95bpm and blood pressure returned to normal. I needed to detox a bit using silica water to get rid of the last of the dementia type symptoms though. Shifting to a meat only diet, got rid of the arthritis.
Unfortunately, a year later, exertion brought back the cardiac issues and O2 saturation problems.
Then I got all my teeth removed as they all now had ceramics. Although they are the best, they are still foreign objects and not seen as the body as self. After the left molars were removed, my O2 saturation problems vanished and I no longer needed my inhaler. My pulse and blood pressure returned back to normal, the pain iny perineum disappeared, myuscles started healing immediately, the hairy tongue and black tongue and candida disappeared. Unfortunately, having to go on a soft diet saw me get nickel hypersensitivity and the tongue problems came back. Then I got nicotine poisoning from patches, but I’m now back to normal, as long as I stay away from fruit and vegetables
https://healthcarenotmedicine.substack.com/p/how-to-trigger-the-human-disease
I subscribe to SAM’s Substack and he has found that our red blood cells in particular are dying, since the roll-out of the covid vax. They seem to be providing energy to the nanorobotics. Some cells are even hexogonal. https://sam368.substack.com/
Start here for more information about nanotech or nanobots: https://shonaduncan.substack.com/p/the-covid-19-show-transhuman-agenda
It is a horror story, I dont’ think we will survive.
This was a long time before the rollout of the mrna gene therapy.
The micronauts only noticed it after they observed the self assembling nanorobotics in the covid injection vials action. Then they found it in everything and everyone. However the US government have been talking about nanotechnology for years
FUTURE STRATEGIC ISSUES/FUTURE WARFARE [Circa 2025].
Denis M. Bushnell, Chief Scientist, NASA Langley Research Centre
Briefly uploaded to NASA website in 2001.
https://web.archive.org/web/20031224161719/http://www.dtic.mil/ndia/2001testing/bushnell.pdf
Nanotechnology on pp 11, 12, 13, 14, 15, 29, 31, 40, 41, 42, 43, 65, 75, 86, 88, 94 and 107
and
The Executive Office Of The President mentioned nanotechnology in the COVID-19 products in 2023.
https://www.nano.gov/sites/default/files/pub_resource/NNI-FY23-Budget-Supplement.pdf
so we can’t act dumb.
There’s no doubt it was the bone cement in my blood supply as symptoms started immediately after surgery in 2019 and I’ve now reversed them by removing all other foreign objects from the body and mouth that the immune system doesn’t recognize as self. I took no supplements or anti-parasitics, or anti-fungals. Just cns suppressants and painkillers. I have now run for the first time in 20 years
I don’t view my own health as a positive. I did however want our species to continue but our governments, who mostly belong to a secret occult society, have other plans. They comfort each other that the Earth is overcrowded and something had to be done, it is a us or them thing. But that is rubbish. The Satanists have been planning it for thousands of years.
I also had a blood smear 6 months after the symptoms started and there was no nanotechnology in my blood at all. So that rules that out.
I knew the cause
I knew how to reverse the symptoms
And I set about doing so.
Reversing the disease process is something I’ve done many times inyself and others, and it’s actually quite easy.
https://healthcarenotmedicine.substack.com/p/how-to-trigger-the-human-disease
Nanotechnology is detectable with dark field microscopy, normal labs wont pick it up. It is a time-lapse thing to watch them self assemble. You are welcome to check out the range of documents and testimonies etc. I am not a scientist or even an expert but I do find it fascinating.
https://shonaduncan.substack.com/p/the-covid-19-show-transhuman-agenda
but some find it downright disturbing and far fetched, maybe because the media hasn’t announced it. The media’s parent companies are the same as Big Pharma: Vanguard, State Street and BlackRock. It would not be in their interests to encourage Vaccine Hesitancy.
Nanotechnology is small enough to cross the blood brain barrier, to get into the nucleus of cells and alter genes with a flick of a switch. It is gene therapy.
I did get dark field microscopy so what you’re actually saying is there is no nanotechnology in my blood from before COVID and long before the gene therapy.
Putting your 10 cents worth in on a strangers health is ok, but not if you keep trying to make excuses why you could be right when you keep getting everything wrong. You’ve made it very clear that you are not the person to be speaking about health, because you keep getting everything wrong.
No, the dark field microscopy I got at the start of 2020 did not show the presence of any nanotech.
Telling everyone that they all now have nanotech in their blood when they haven’t even been tested is also very strange.
I am qualified to talk about healthcare and medicine. You don’t need a medical degree to do so. Most doctors claim ‘the vaccine is safe and effective’ but obviously they are blowing it out their arse for the money if they know so much more than me.
People from different disciplines are adding their voices into the great mysteries from the Covid era, including journalists and patients (shocking, they don’t even have the jargon rote learned).
I assume everyone has nanotechnology in them because 6 billion took the injection and the nanotech apparently seeds into the environment through shedding and it is in the Brisbane tank water, so the rain too.
There is nanotechnology in the covid injections and the diagnostic products, and you can read that in the Presidential budget 2023 I gave you.
NASA wrote in a 2001 future of war document that by 2025 there would be nanotechnology in everyone and everything.
I would not expect nanotechnology to show up at the start of 2020. Did you get the date wrong?
You can talk about what you want, but when you keep looking for an excuse to prove it was due to nanotech in my blood even after dark field microscopy was done prior to COVID and the gene therapies you start to sound ridiculous. I know what the cause of my bad health was(an accident during back surgery) which I’ve already explained, and how I also reversed the disease process, and have now restored my health back to a good state. So you certainly don’t have the knowledge to be commenting on the health of complete strangers, otherwise you would have listened and got it right, instead of insisting it’s nanotech in my blood.
There is no way for anyone to know whether the entire population has nanotech in them or not, but my hypersensitivity to metals suggests I would notice.
I honestly don’t care what was in your blood. I do not even like you.
Lab results of various Covid-19 injections suggest there are heavy metals and uranium. “Among the undeclared chemical elements were detected 11 of the 15 cytotoxic lanthanides used in electronic devices and optogenetics.”
At Least 55 Undeclared Chemical Elements Found in COVID-19 Vaccines from AstraZeneca, CanSino, Moderna, Pfizer, Sinopharm and Sputnik V, with Precise ICP-MS (October 2024).
https://www.researchgate.net/publication/384844917_At_Least_55_Undeclared_Chemical_Elements_Found_in_COVID-19_Vaccines_from_AstraZeneca_CanSino_Moderna_Pfizer_Sinopharm_and_Sputnik_V_with_Precise_ICP-MS
uD83DuDE02your 7 other text messages suggest otherwise. What was in my blood is still in my blood. A blob of acrylic in your bloodstream can’t be removed without leaving me worse off.
Luckily I wasn’t stupid enough to get the mrna gene therapy injected into me.
I used to go to school with wankers like you but thankfully I did not meet them at university. I don’t know why you think you would have nanobots in your blood early 2020. The shots weren’t rolled out until early 2021. The self assembling nanotechnology has been observed everywhere now, even insulin and dental anaesthetics. Have a nice life.
I never thought I had nanobots in my blood at any stage, you are the one who introduced that assumption to the conversation. Perhaps you need to read the comments again as now you’re imagining things.
You think the nanobots have been found everywhere including insulin and dental anaesthetics, but you have no clue as to whether you are correct or not.
I’ve had 4 dental anaesthetics this year which lead to huge improvements in my health, so obviously they weren’t in the dental anesthetics I was given were they.
University is where people with good intentions get brainwashed with false information to describe the public, mainly in the life sciences. That’s where Drs are taught to tell bullshit to patients, in order to protect industry from liability at the expense of the patients health.
If you wish, pls look at Nixonlab (David Nixon) work on Substack or at SAM also on Substack. Very informative.
I have spoken to David and sent him my blood smear to look at.
While many have nanotech in their blood, it is not possible to say that every human does based on assumption.
It’s like those scientists who think that seasonal illness doesn’t exist when many get seasonally ill.
Or the ones who think contagion doesn’t exist because no western scientist has designed the right test to prove it. They think they are the most clever scientists in the world and that no future generations scientist will design the right study and prove it.
A while back, some scientists were adamant that heavier than air flight is impossible. They sure turned out looking stupid.
If nanotech is in all dental anaesthetics then they have improved my health enormously. How could nanotech improve your health so much, especially when you are hypersensitive to metals like I am.
If I did have nanotech in me, I would certainly know as it would cause very bad symptoms due to my hypersensitivity to metals.
So how can metals cure metal hypersensitivity?
The biggest logic trap anyone can fall into is to think that something isn’t true unless a scientist has proven it, and here on substack there are many scientists who have fallen into this logic trap.
It’s like saying the sun doesn’t exist if it hasn’t been proven to exist by scientists. Logic does not always dwell in the minds of those we think it does, and it’s because they’ve been trained to believe the false notion that something isn’t true unless a scientist has proven it to be true, even though it will likely be proven in the future. These people are ignorant and arrogant and their logical thoughts were taken from them at medical school
Thank you for your response. I consider it enlightening.
Before there was orthodox medicine there were the ‘wise women’ (witches) who also performed midwifery. I don’t know why people feared the witches and not the people who burned them alive.
You aren’t a very wise woman.
God help you, ladyu2026 You must be one.
It is enormously satisfying to be more informed than most people. In the immortal words of Stephen Hawking u2014 u2018The thing about smart people is that they seem like crazy people to dumb people.u2019
Well, u201Cit is easier to deceive a man than to convince him heu2019s been deceived.u201D You can also apply that to yourself.
Why does truth make you angry? I publish links to source documents, there is no original content in anything I publish, I do not even attempt to interpret my findings. I am not telling people what to think, but how to think while presenting information that is outside the MSM authorised narrative. My select-bibliography formatting is original, though only on Substack, you will find similar formatting in any formal database. People like you and Mark.Kennard lose your minds over that and it is incredibly interesting. Who do you work for?
Any experience or knowledge of DMSO alleviating or treating neuropathy symptoms?
I would use it topically and orally if I had those.
DMSO, IVM and fenben has a lot of health benefits it helps in getting rid off cancer, chronic pain, PTSD, anxiety and depression
Go to my profile description it has a link to the doctor who healed my fatheru2019s cancer, psoriasis and parasites cleaning within weeks using those meds
Can you use IVM and DMSO on the same day, say 4 hours apart. I read somewhere that they shouldn’t be used together at all.
If youu2019re dealing with any health difficulties,Iu2019ll suggest you send a message to this email [email protected], It leads to the doctor who resolved my fatheru2019s cancer, ADHD, and other mental illness within weeks using her innovative ivermectin, fenbendazole, and DMSO protocol.
This information is very helpful & much appreciated. Thank you.
if you have garlic breath you using the wrong grade of DMSO, use the 99.95 or better and most of the smell gos away, if your wife can smell it then give her a foot rub and secretly put some on here feet, she wont be able to smell it anymore.
Take activated charcoal and/or chlorophyll, which will help
Chlorophyll definitely helps, but I’m getting high-dose C/DMSO IVs weekly and I’m really fragrant for about 24-48 hours after a treatment. We got into the car after my first treatment and my wife inexplicably cracked the windows. (This was in mid-January.) I thought at first it was a hot flash, then she explained it was my aroma! Needless to day my “dance card” is empty for that interval. I was going through one of AMD’s recent articles on DMSO and followed a link to an earlier article where she recommended urea powder for the odor. Do you know anything about this?
Where does one get intravenous DMSO?
One would need to see an MD who advertises as an “Integrative practitioner,” or something like that. Contact their office and inquire. The particular MD I see advertises it.
Thank you for this gift. AMD is certainly an exhaustive source of informations on DMSO and too detailed for a person without medical knowledge, so I appreciate your summary and comments. I have certainly used it successfully for pain relief from tendonopathy which the pharmaceutical painkillers didn’t touch.
That is very useful, thank you 🙂
Thanks bunches for the Cliff notes Dr. Yoho. I drown in AMD wordiness and science. An easy and quick read is a book from Amanda Volhmer with mixtures for DSMO is 2.99 on Kindle – def worth the $ and the read/mixtures.
Love it
I have used DMSO many times. I bought it to try and resolve tinnitus but havenu2019t been able to set aside the time to test it on that yet.
What I did find remarkable was itu2019s effectiveness with Cervical Spondylitis! I was diagnosed with that and the only recommendation from my doctor was to put heat on the area. The relief ended quickly once I removed the heat pad.
I then used the 4 most hated words by doctors, I u201Cdid my own research.u201D I then applied DMSO and the nerve tingling was gone in 3 days, the pain was gone in 5 days! The pain returned in a milder form about a month later and again about 3 months later. Both times it only took a couple of days of DMSO to resolve and, as of today, itu2019s been nearly a year since I last had any pain at all!
Iu2019m now using it on my leg as I have pain in and above my knee. The pain is slowly going away.
Itu2019s a miracle treatment that cannot be patented so you will rarely hear the benefits from any corporate doctor!
Have a great, blessed, and, hopefully, pain free day!
Love it
May I ask what you did to cure the tinnitus?
Unfortunately, I have not cured the tinnitus. I have had it for over 25 years. I recently read of people who were successful in treating it with DMSO and decided to give it a try.
I started but found it too difficult for me to continue. The method described involved dripping it into each ear twice a day and laying with the ear facing up for 10-15 minutes.
I expect to try again but canu2019t right now because of my hectic schedule.
Thanks for the reply Andrew.
You are most welcome!
Bard Joseph
Everyone falling for this to now push a new drug market.
Fool me once….
What happened to Essiac tea and B17 Apricot seeds?
Wormwood tea also kills parasites.
This is just a new product line for the drug trust.
Ya not a guinea pig y’all.
Fool me twice……
CANCER WAS PUT IN THE POLIO SHOT SV 40 Simian Virus.
Read Dr. Mary’s Monkey.
Dont get fooled again.
https://youtu.be/KjmjqlOPd6A?si=3LRO6FNjBg_GaJKc
It takes a long time to read through AMD’s recent substack, but just think of all the work she/he has done. I’m a big fan and use DMSO twice a day on my knees and other areas. My husband has Parkensons Disease too. I hope to figure out how to help for him having just found you. B1 seems to help and hope to get the dose higher soon. Thanks for the summary
Iu2019m waiting for an MRI to see if, as my doctor suspects, I have a compression fracture in a thoracic vertebrae. The pain level and spasms are, shall we sayu2026exquisite.
After reading this today I went into my medicine cabinet and sprayed my 50% DMSO solution (I use for arthritis in the hands) on that area of my spine. Iu2019ll mix up a 70% solution and apply daily for a while. I donu2019t know why I didnu2019t think of this before, certainly nothing my doctor has prescribed even touches this level of pain.
Make sure your radiologist does NOT use a contrast agent with your MRI. See Dr Yohou2019s post about gadolinium contrast agents.
https://robertyoho.substack.com/p/radiologists-deserve-the-same-contempt
They are evil bastards.
My doctor specifically ordered it without contrast. Iu2019d already read the substack entry you referenced, thank you!
Take it orally and read Hormone Secrets for my advice about osteoporosis. Word search the PDF for this.
Thank you, Dr Yoho, for this amazing abstract of AMDu2019s epic tome. I subscribe to AMDu2019s Substack and read the original article over two days, but I have to say that, even though Iu2019ve been reading clinical trials and u201Cofficialu201D medical reports for most of my adult life, I continue to struggle with AMDu2019s extreme comprehensiveness. For example, your section on u201CCognitive impairment, dementia, and memoryu201D is three paragraphs; the original is 49 paragraphs that chronicle improvement using DMSO alone and in combination therapy with over 100 agents (none of which include dosing instructions) in both animal and human studies.
Itu2019s frustratingly difficult to get exact dosing instructions for DMSO combinations. Even the Russian Psychiatric Study conducted by Moscow Medical Academy in 1999 is not exactly complete. As you and AMD reported, the DMSO/Vitamin E oral combination is 50 mg/5 mg per kg, but neither AMDu2019s original article nor the linked English abstract of the Russian study give the time frame. Was it q.d., b.i.d, once and done, or what? Fortunately, neither DMSO nor Vitamin E have a slim therapeutic range, so I guess a provider can just keep increasing the daily dose until the voices go away. 🙂
Thanks for that comment. I think the stuff is nearly harmless, and so I take that large dose right now, but I could be wrong and offer no guarantees. All my best.
Can you be more specific and how this works for restless leg syndrome please
Excellent work Sir. I live in Canada and suggesting to a Doctor that I want DMSO IV for a treatment is laughable. What would be a suggested dose orally for DMSO disc and back pain in a 250 lbs individual. I am a retired Equine Veterinarian and have used DMSO since 1985.
You can read AMD’s write-up in its paywalled area of the Substack, but the answer is unclear. If it were me, I would take several tablespoons a day, and as you may have read, I’m taking up to ten now. This may not be the smartest move.
Thanks for breaking AMDu2019s book down into an easier distillation.
My non-medical advice question is how do you overcome the smell? You once said your wife threw you out of the house because you reeked of it. Iu2019m using DMSO for arthritis but Iu2019m only brave enough to use it topically as this minimizes the odor, at least for me.
Oral activated charcoal and/or chlorophyll
Thank you!
I have tried 2 different brands of DMSO. All I smell is rotten milk. When my significant other takes it, I cannot tolerate his smell. Anyone have a similar experience, or am 8 receiving bad DMSO?
I was taking Chlorine Dioxide at about 30 drops a day for some months before starting DMSO. I attribute the headstart I got on CD to why I didn’t smell much on DMSO (or so my husband swears).
Are you using pharma grade 99.995% dmso? it makes a difference. Here’s my video about dealing with the stink. https://youtu.be/jtUpVBLUjKo
My greatest fear is that they pack DMSO full of nanotech and/or worse things. Any take on that?
My kids don’t listen to me either, grin. I am so impressed with the quality of your research and your willingness to research non-Pharma healing remedies. Thank you very very much for sharing. I quite simply think that your are amazing.
On another subject, Dr William Makis, perhaps we need to give him a little leniency. The government and Medical licensing boards in Canada are vicious supporters of pharma. Over 200 Doctors in Ontario lost their licenses during cvd for offering their patients informed consent. I worked with an MD who practiced Functional Medicine. The College of Physicians and Surgeons in Ontario hounded this poor man, who didn’t want to be a marketer of pharma products. These colleges are ruthless. It could be that Dr Makis was/is a victim of Alberta Health Services. And, from what I see, in the cases that he publishes, people are benefitting and healing from antiparasitic and natural protocols.
Thank you again for being so great!
Laurie
Youu2019re not wrong about the broader context.
The Canadian medical licensing system did treat many good doctors horrifically during COVID. The persecution of physicians who offered informed consent or practiced outside narrow pharmaceutical guidelines was real, documented, and beyond disgraceful. We should have no illusions about what the Colleges are capable of, and anyone who assumes a cancelled licence automatically means u201Cbad doctoru201D hasnu2019t been paying attention these past few years.
But we should also be careful not to conclude that everyone the College goes after is a good egg. Makisu2019s case is not that.
His licence was not cancelled for prescribing ivermectin or offering informed consent. It was cancelled in 2019, after he had already been barred from practising in 2016, years before COVID. The cancellation followed findings of professional misconduct that included sexual harassment of nurses, with multiple colleagues testifying under oath. The zoophilia admission is on his disciplinary record. The vexatious-litigant designation came from an Alberta judge who had seen enough of his litigation pattern to formally restrict his access to the courts. None of this has anything to do with pharma, medical freedom, or Alberta Health Services retaliating against a dissident.
As for patients benefiting from antiparasitic and natural protocols: many are. But in a context where Makis has not invented any of these treatments, that is precisely why the record matters. People trusting someone with their health deserve to know whom they are trusting. A pattern of abandoned patients, unverifiable testimonials hosted on commercial partnersu2019 websites, and redirection of immunocompromised cancer patients toward CBD providers with no legitimate lab testing is not something we can look away from just because the broader cause is right.
The cause is right. That is exactly why it cannot afford to be anchored to someone whose behavior puts it at risk.
This was much more in depth than many writeups. It was so awesome to get a confirmation of where my lucid dreaming was coming from. I’ve always had sleep issues and who would have thought stand alone DMSO understand better what to do than I do. Am pleased with low dose DMSO and am investigating peptide absorbtions..uD83DuDE4F
Dr. Yoho – One time you said you wished you used DMSO on your shoulders before having them replaced. What would you have used with the DMSO on your shoulders, if you could go back?
HELP My cousin male 69 had to have emergency surgery due to (gangrene and Sepsis). The type of surgery caused him to have to go under anesthesia 6 times for wound care. Re: Anesthesia to clear his system as his brain is a bit messed up at times? Is this something that can help him. TY for any help.
Dr. Yoho – Iu2019d like to try DMSO for arthritis, but just had double hip replacements in December. Iu2019ve been told they are titanium and ceramic, with some type of super-strong plastic lining the socket. I guess Iu2019m hesitant to try DMSO in apprehension that it may possibly react in some way with the hip implants(?)u2026 I havenu2019t yet queried the hip surgeon, but if thereu2019s information on this subject that could reassure me, Iu2019d love to have access to it! Thanks muchu2026
Does anyone know how I could print Dr. Yohou2019s stacks about dmso?
on my Windows pc this is one way: Go to File/Print (or press the u201Cctrlu201D and the u201Cp-letteru201D key at same time), should get a u201CPrintu201D window popup, chg ”Destination” to u2018Save to PDFu2019, and you have a download, printable, and can later search it with key words/phrases
Thank you!
Thank you so much. We are going to start applying DMSO along my husbandu2019s spine. He was diagnosed with multiple systems atrophy – cerebellar subtype in Nov 2021.
https://substack.com/@davidwaterman3/note/p-190731638?r=15vmqh copy past and let’s have a good viral time. Easy websites for senators Johnson and Dr Paul the Whitehouse USDOJ USHHS and more
DMSO saved me from knee surgery. I tried it only because surgery was the only option left to me, I did not want to have to go that route and some of my substack readers sent me various formulations of DMSO and it WORKED.