RESOURCES: THE APOCALYPSE ALMANAC. Fun, treatments, cures. FULLSCRIPT SUPPLEMENTS: Top quality, economical.
Table of Contents
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Yoho Preface
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Polymath Paul’s introduction
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Glycine and GlyNAC: Simple Supplements with Profound Health Benefits
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Paul says to consider TTFD
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Synthesis
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Sources: an AI search I did for you and some references
Yoho Preface
I am at the point where, to preserve my sanity and ability to swallow supplements without thinking about barfing, I must give up some of them. Items that might be best taken on an empty stomach, such as glyNAC, sometimes present the most problems. My Parkinson’s tremor and balance problems have worsened, and I suspect some of the damn pills I am taking are the culprit. So, I am on a supplement fast for a week, except for lithium, DMSO, iodine, and a few others.
I have been taking glycine without NAC (N-acetylcysteine) for about three weeks, and have experienced increased energy, improved sleep, and possibly some relief from ankle arthritis. I am having trouble tolerating NAC and would like to learn how to disguise the taste. To learn more about how to handle this and more, download my AI search in the Sources when you are done reading.
Polymath Paul Sansonetti’s introduction
I was concerned about Robert and recommended glyNAC, which is a combination of glycine and NAC (N-acetylcysteine). I told him that this and “TTFD,” a bioavailable thiamine, made me feel like Superman.
The combination of glycine and NAC offers incredible benefits:
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It boosts glutathione, which makes it harder to get a sunburn.
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It speeds up collagen production and turnover, which rejuvenates the skin and helps eliminate any problem areas that may become cancerous.
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Glycine helps sleep and is anti-inflammatory. Your ankle arthritis should improve.
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It starts working in a few days.
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There are no known harmful effects.
Sources and how to take glyNAC:
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The least costly sources are powder from BulkSupplements.com or PureBulk.com.
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The dose I take is 10 grams each of glycine and NAC. [Yoho: See below; smaller amounts are also beneficial.]
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Some recommend divided doses, but taking one large dose in the morning on an empty stomach is often the easiest. You mix it in a glass of water, or better, something like orange juice that will mask the taste.
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Glycine tastes OK, like a weak sugar.
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NAC, due to its sulfur group, has a pungent, rotten egg-like odor to most people. I need to find something that hides this.
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One kilogram of glycine for $32 is HERE.
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One kilogram of powder NAC is available HERE for $41. [The AI search has other options.]
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Ten grams a day of each lasts me approximately 100 days.
[Yoho comment: Paul also recommended five mg of lithium orotate for me, and I told him I am already taking 10. It is over the counter, harmless at these doses, and it somehow calms brain neurons. It is available HERE.]
Back to Paul: I use these as nootropics to enhance my functioning. My brain now feels like it has a lot more energy, and my ability to focus is incredible. This also helps cure fatigue and lack of stamina.
I would seriously recommend trying glyNAC and TTFD for a month or two, homie.
[Yoho comment: Paul is a true polymath, and his research always adds up. He has more about TTFD later.]Glycine and GlyNAC: Simple Supplements with Profound Health Benefits
by Robert Yoho
Glycine is the smallest amino acid. It drives protein synthesis and produces critical molecules, including creatine, glutathione, heme, and purine nucleotides. Though the body makes it from choline, serine, and threonine, production falls short of what we need.
The liver converts glycine into glucose, providing energy during fasting or low-carb periods while preventing carb cravings and replenishing muscle glycogen stores. Low doses of 1-3 grams don’t disrupt ketosis, which makes glycine valuable for ketogenic diets and intermittent fasting.
Why We’re All Deficient
Under normal conditions, humans, animals, and birds are unable to produce sufficient glycine. Some regard it as a nearly “essential” amino acid—a substance the human body cannot make and must therefore obtain from the diet. This bottleneck limits the body’s efficiency. Food additives like benzoates in soft drinks and processed foods bind available glycine, further depleting it. Low levels compromise essential enzyme and protein production, affecting multiple body systems.
Glycine Transforms Health
Collagen and Skin
Glycine makes up one-third of collagen’s amino acids. As collagen production declines with age, the skin becomes looser, wrinkles appear, cellulite increases, joint pain develops, and muscle building becomes more difficult. Taking 10 grams daily improves collagen synthesis by 200%. In elderly women, glycine acquisition through collagen intake improves skin elasticity, enhances moisture, and reduces water loss. A dose of 2.5 grams of collagen peptide for four weeks resulted in a 20% reduction in eye wrinkles, with benefits lasting beyond the study’s conclusion. In 89 patients in long-term care facilities, glycine nearly doubled the healing speed of diabetic skin ulcers.
Muscle and Athletic Performance
Glycine fuels creatine production, which is stored in muscles and provides rapid energy during intense exercise. Without sufficient glycine, the body cannot produce enough of it, which limits muscle strength and mass gains. Glycine may enhance peak power output, reduce lactic acid accumulation during high-intensity exercise, and improve the quality of recovery. High doses trigger the release of growth hormone from the pituitary gland, stimulating protein synthesis, building muscle, and promoting faster recovery.
Glycine prevents muscle breakdown while boosting recovery by providing cellular energy and increasing ATP production in working muscle tissues. This improves endurance, strength, and performance. Steroid hormone synthesis improves, decreasing the fat-to-muscle ratio.
Sleep and Brain Function
Glycine is also an inhibitory neurotransmitter that controls nerve signals in the brain and spinal cord, producing calming effects that promote relaxation and better sleep. Taking three grams before bed decreases the time needed to fall asleep, improves sleep quality, and reduces daytime sleepiness. It induces vasodilation throughout the body and lowers core body temperature, a critical trigger for falling asleep. Longer-term use improves sleep in healthy people while enhancing REM sleep patterns and decreasing non-REM sleep phases.
Heart Protection
Glycine fights inflammation by modulating nuclear factor kappa B (NF-κB) expression in many cell types. Higher glycine levels are associated with improved heart protection, likely due to their anti-inflammatory properties. Glycine protects against arterial narrowing and reduces platelet clumping, which causes heart attacks and cardiovascular disease. People with higher plasma glycine levels have lower risks of heart disease and heart attacks. The amino acid also helps lower blood pressure in certain populations.
Blood Sugar Control
Higher serum glycine levels are associated with lower insulin resistance, improved insulin sensitivity, and reduced abdominal fat—all factors that contribute to a lower risk of metabolic disorders. Glycine reduces glycated hemoglobin levels, thereby improving glucose management in people with type 2 diabetes. It stimulates the release of glucagon, which helps insulin remove glucose from the blood. Better glucose regulation benefits everyone by maintaining steady blood sugar levels throughout the day and preventing energy crashes.
Liver Protection
The liver relies on glutathione, the body’s most powerful detoxifying substance, and glycine is essential for making it. Most glutathione synthesis occurs in the liver, but stores deplete easily. Glycine protects against alcohol-induced liver toxicity by reducing blood alcohol levels and metabolic byproducts while lowering gastric emptying rates. It helps those who consume excess alcohol by reducing harmful cholesterol, free fatty acids, and triglycerides in the blood, liver, and brain. It slows damage from liver injuries or disease.
Mental Health
After long-term glycine use, psychiatric symptoms decrease. It reduces symptoms of schizophrenia, obsessive-compulsive disorder, and depression. Glycine calms overstimulated brain states while lowering stress and manic-like brain activity. Small amounts dilate brain microvessels by up to 250%, improving cerebral circulation.
Immune Support
Glycine reduces pro-inflammatory cytokines and free fatty acid concentrations while improving insulin response. It promotes anti-inflammatory effects by regulating the function of immune cells. As a precursor to glutathione, it eliminates toxic compounds and protects cells from oxidative stress. In animal models, glycine reduces inflammation, morbidity, and mortality from infections.
Practical Use
Most studies showing benefits use 3-10 grams daily, often split into 2-4 servings. Some research has used doses as high as 80-90 grams per day for several weeks without serious side effects. Doses above 40 grams per day may cause nausea and vomiting in some people. Massive doses over 500 mg per kilogram of body weight can cause kidney and liver toxicity and brain toxicity, causing neuronal death.
For most people, starting with 3-5 grams daily works well. Individuals seeking sleep benefits should take glycine 30-60 minutes before bedtime, while those targeting exercise performance or recovery may benefit from taking it pre- or post-workout.
Yoho note: I used three grams of the supplement in water at night on an empty stomach for two weeks with no noticeable effect on sleep. When I started taking 10 grams, my sleep improved dramatically within three days. To measure glycine, I purchased a $20 milligram scale HERE and some plastic scoops. I placed a 1-teaspoon scoop on the scale, zeroed it, and then found that when I filled it with glycine, it weighed 3.3 grams. I now mix three scoops in a glass of water and drink it nightly.
Food Sources
Glycine is concentrated in certain cuts of meat, such as chuck, round, and brisket. Bone broth provides large amounts through its gelatin content. Collagen supplements also deliver substantial glycine, as do glycine supplements in powder or capsule form. Powder forms mix easily into water and cost little, while capsules provide convenience for those who dislike the sweet taste. (Yoho comment: I like it.) Since all glycine supplements are the same, there’s no need to pay premium prices. HERE are Amazon sources.
GlyNAC reverses aging at the cellular level
With age, energy levels decline, muscles weaken, cognitive function slows, and the risk of disease increases each year. A combination of glycine and N-acetylcysteine (NAC) can reverse much of this. GlyNAC has been proven effective in older adults, who experienced remarkable improvements in energy, strength, cognitive function, and cellular health in rigorous clinical trials.
How GlyNAC Works
GlyNAC generates glutathione, which protects cells from free radicals. Glutathione gets used up as it’s produced and must be constantly replenished. With age, people make less of it, leaving cells more vulnerable. Research at Baylor College of Medicine showed that older adults have 66% lower muscle glutathione concentrations than young adults.
This deficiency leads to elevated oxidative stress, mitochondrial dysfunction, inflammation, endothelial dysfunction, insulin resistance, multiple hallmarks of aging, impaired physical function, increased waist circumference, and elevated blood pressure. Mitochondria are vulnerable, and when they fail to function correctly, cells lose their ability to generate energy efficiently. This produces fatigue and weakness. When damaged mitochondria produce more harmful free radicals, it becomes a downward spiral. Glutathione depletion continues, leading to further cellular damage and dysfunction.
The primary reason for glutathione deficiency in older adults is decreased synthesis caused by a reduction in its two primary building blocks, glycine and cysteine. This produces a complex web of problems that emerge with advancing age.
Glutathione cannot be absorbed when taken directly as a supplement; the body must make it internally using raw materials. GlyNAC is glycine and N-acetylcysteine (NAC), the two amino acids required for glutathione synthesis. Taking both improves glutathione concentrations by 121% after just two weeks and by 164% after 16 weeks, restoring levels to match those in young adults.
Glycine and cysteine are both essential for cellular health. The researchers who developed glyNAC refer to the “Power of 3” concept—the combined effects of glycine, NAC, and the resulting glutathione production. This produces improvements that exceed the impact of any single component.
GlyNAC triggers a cascade of positive changes that help maintain the delicate balance that promotes overall health. With glutathione levels restored, mitochondria can function efficiently again, inflammation decreases, and cellular repair processes resume normal operation.
Clinical Results
Controlled clinical trials show glyNAC’s dramatic effects on aging. A landmark study at Baylor College of Medicine found that older adults taking it for 16 weeks showed improvements in several areas, including oxidative stress, glutathione deficiency, inflammation, insulin resistance, endothelial dysfunction, genomic damage, stem cell fatigue, and cellular aging. Multiple aging hallmarks that affect mitochondrial dysfunction improve.
The subjects’ muscle strength, waist circumference, and blood pressure all showed positive changes. GlyNAC for 24 weeks increased gait speed in older adults to match that of young adults, while enhancing muscle strength and exercise capacity.
Cognitive benefits are impressive. Research in aged mice has shown that glyNAC improves brain glutathione deficiency, oxidative stress, glucose uptake, mitochondrial dysfunction, genomic damage, inflammation, and neurotrophic factor levels, thereby reversing age-associated cognitive decline. Human studies confirmed these findings, with older adults experiencing significant improvements in memory and thinking ability when using glyNAC.
GlyNAC is safe and well-tolerated. Many benefits become evident within just two weeks of starting. It leads to reversal of aging markers—improvements in mitochondrial function, mitochondrial biogenesis, intercellular communication, nutrient sensing, protein maintenance, stem cell exhaustion, genomic damage, cellular senescence, and telomere attrition.
Animal studies show longevity effects. Mice receiving glyNAC starting at 65 weeks of age live significantly longer than control mice.
Sources
GlyNAC can be obtained through separate supplements of glycine HERE and N-acetylcysteine HERE, or these can be purchased as a combination. [See the AI search at the end for more definitive recommendations.] GlyNAC has better effects than glycine or NAC individually because glutathione synthesis requires both in optimal ratios.
GlyNAC is marketed in the United States by Nestlé Health Science under the name Celltrient Cellular Protect. However, Nestlé did not provide financial or material support for the research work that established GlyNAC’s benefits.
Safety
Clinical trials consistently report that glyNAC was safe and well-tolerated, with no significant adverse events. Use for 24 weeks in older adults produced improvements without substantial side effects.
NAC can cause nausea, vomiting, and diarrhea in some individuals, though these effects are rare. Starting with lower doses and gradually increasing them may help minimize this. Some report that NAC supplements have a naturally occurring sulfur smell, and if this were not present, they would question the efficacy and freshness. This odor is unpleasant but indicates that the NAC is active.
When NAC or glyNAC is taken intravenously, into the veins, an NAC overdose is possible. It can result in red blood cell breakdown, low blood platelet count, kidney failure, and possibly death. However, this concern applies only to intravenous use, not oral use at recommended doses.
GlyNAC may interact with blood thinners and chemotherapy drugs through its effect on glutathione. Other potential interactions include effects on blood pressure medications and antipsychotic drugs, particularly clozapine, which may have reduced effectiveness when combined with glycine.
Yoho comment: Clozapine is an atypical antipsychotic—a fraudulent psychiatric drug that has never been tested against placebo controls and reduces lifespan by 10-20 years. See Butchered by Healthcare for the whole story. Stay away from this class of poisons.
In rare cases, NAC supplements have been associated with elevated liver enzymes. Pregnant and breastfeeding women should avoid glyNAC because it has not been studied for them.
Excessive antioxidant use with glyNAC can theoretically induce reductive stress rather than beneficial effects. However, glyNAC lowers oxidative stress markers without decreasing them below levels seen in young adults, thus avoiding reductive stress. This suggests that glyNAC works physiologically rather than pharmacologically, supporting natural cellular processes rather than overwhelming them.
Dosing and outcomes
A teaspoon of glycine is approximately 3.3 grams, and NAC is lighter, so you need a larger volume of that. Again, to learn how much, buy a $20 digital scale HERE, zero it with your plastic teaspoon scooper on it, and then measure the weight of a full scoop.
Clinical trials use about 100 milligrams per kilogram of body weight per day of glycine and 133 milligrams per kilogram per day of N-acetylcysteine. For a person weighing approximately 150 pounds (68 kilograms), the recommended daily dosage of NAC and glycine is approximately 9 grams and 7 grams, respectively. However, many practitioners recommend starting with lower doses to assess tolerance and response.
Some begin with 600-1,200 milligrams each of glycine and NAC daily. More aggressive protocols may use three to seven grams of each daily. Some split this into 2-3 divided doses throughout the day.
GlyNAC for 16 weeks or 24 weeks yields similar outcomes. Withdrawing GlyNAC for 12 weeks results in a loss or decrease in benefits.
A randomized controlled trial in healthy older adults tested three different daily doses for two weeks—low dose (2.4 grams), medium dose (4.8 grams), and high dose (7.2 grams) in a 1:1 ratio of glycine to NAC—and found significant improvements in glutathione levels and oxidative stress markers even in healthy individuals.
GlyNAC and Parkinson’s Disease
Recent research suggests that energy deficits may drive Parkinson’s disease at the cellular level, and glyNAC may offer help. Reader Daniel Weigand, a 25-year cancer survivor who uses unconventional methods, directed me to the Georgi Dinkov site, “To Extract Knowledge From Matter,” which contains compelling information on this.
Mitochondrial Dysfunction Drives Parkinson’s
Research from the University of Copenhagen shows that 90 to 95 percent of all Parkinson’s cases are caused by a blockage in a pathway that regulates the nerve cell’s powerhouse, the mitochondria. When brain cells have this specific kind of signaling blockage, the mitochondria cannot be cleaned up after being damaged. This leads to the accumulation of a high number of damaged mitochondria that are unable to produce enough energy for the cells. This causes neurons to gradually die, which is the reason for the development of Parkinson’s symptoms and why it leads to dementia.
Energy Deficiency as the Root Cause
Computational modeling by IIT Madras researchers revealed that energy deficiency may be a significant contributor to the loss of substantia nigra pars compacta (SNc) cells, the brain cells involved in Parkinson’s disease. These studies suggest that metabolic deficiency within the basal ganglia circuit is the common underlying factor at the subcellular, cellular, and network levels in Parkinson’s disease.
This energetic deficiency would explain both the serotonin excess seen in Parkinson’s patients and the positive effects of anti-serotonin/pro-dopamine drugs. It opens the avenue to several metabolic therapies for Parkinson’s, including reduction of endotoxin/LPS, and usage of over-the-counter substances like aspirin, niacinamide, progesterone, DHEA, testosterone/DHT, salt/baking soda, quinones (methylene blue, vitamin K, tetracyclines), and anti-estrogenic substances, among others.
Yoho comment: Dinkov was brilliant but not a clinician. Progesterone supplementation for men causes heart disease, according to my hormone mentor, Neal Rouzier. Stay away from it unless you have XX chromosomes. Also, there are many reasons to avoid anti-estrogens; see Hormone Secrets.
Since GlyNAC restores mitochondrial function, reduces oxidative stress, and improves cellular energy production—the exact deficits seen in Parkinson’s disease—it may offer potential as a treatment.
Additional Resources:
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Disruption of mitochondrial complex I induces progressive Parkinsonism
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Mitochondrial Dysfunction Enough to Cause Parkinson’s in Mice
[Yoho: Thanks, Daniel; you have motivated me to reconsider that nasty-tasting NAC. Please stay in touch and let me know if you find a way to disguise the taste.]
Paul says to consider TTFD
Here he is again:
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Substantial clinical reports say high-dose thiamine in several gram doses harmlessly relieves Parkinson’s symptoms. [Yoho: I could not tolerate all the pills, but when I read about TTFD, I started taking that.]
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Thiamine tetrahydrofurfuryl disulfide is a derivative of thiamine (B1) that is more bioavailable and readily absorbed than the original. It is used for health maintenance and disease therapy and serves as a synthetic counterpart to allithiamine, which is found in garlic. TTFD offers several potential benefits, including improved energy metabolism, better nerve function, and a boost in physical performance.
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TTFD can help improve the body’s ability to convert food into energy, potentially leading to increased stamina and reduced fatigue.
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It supports healthy nerve function, which is crucial for various bodily processes, including muscle control, digestion, and cognitive function.
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TTFD can improve physical performance and endurance, particularly during periods of fatigue or exercise.
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TTFD is a more fat-soluble form of thiamine, which may help with absorption and utilization of the vitamin.
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It is believed to cross the blood-brain barrier, potentially increasing thiamine levels in the brain and supporting cognitive function.
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It can help support the proper functioning of the heart and cardiovascular system.
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TTFD may improve digestion.
HERE is the brand I bought; the dose is four 50 mg capsules a day, and HERE are other purchase options on Amazon.
TTFD Reference:
Vitamin B1 enhances physical activity and wakefulness by raising dopamine —From Georgi Dinkov’s website To Extract Knowledge From Matter
Synthesis
GlyNAC is among the most effective and inexpensive anti-aging interventions ever discovered. Memory, energy, and brain health improve. The evidence supporting the combination comes from rigorous clinical trials conducted at medical institutions, not from marketing claims. Older adults who take glyNAC experience measurable improvements in energy, strength, thinking ability, and cellular health. The safety profile is excellent.
You can take NAC and glycine in combination form or separately. They are available in capsule or powder form. NAC tastes like sulphur, so it may be hard to stomach. Read the AI search at the end, and possibly some of the references I provided for ways to overcome this. These agents are generally considered harmless, and you should learn what works for you by gradually escalating your dose and watching your results, as I did.
And yes, my sleep improved when I started taking ten grams of glycine a day alone. Since I have Parkinson’s, it is still imperfect.
Sources
An AI search I did for you
For more details or to fact-check, download and scan this AI search. It is a bit crude but has additional info about timing, benefits, quality sources, and doses lower than ten grams.
References
DownloadEditing credit: Elizabeth Cronin (thanks for your patience with this one) and Jim Arnold of Liar’s World Substack.
Restacking this post is super helpful. To do this, locate the restack icon and click or tap on it. This is a circular arrow icon usually found near the content.
To learn how to help me without spending money, read THIS.
Yoho disclaimer: You know the drill. Although I found no significant adverse effects from oral glyNAC at the discussed doses, I am telling you what I am doing, not giving you advice about your health. If the combination turns you into a werewolf, it is on you and not me.
Parting Shot, A testimonial about Dr. Tamara:
Dear Dr. Yoho,
I want to thank you so very much for the referral of Dr Tamara Santa Ana. She has a wealth of information and great understanding of the health field. She is such a kind and loving person, and it is obvious that she wants to help people heal and be healthy. I have read your books and follow your posts and Substacks with much passion. Thank you for all that you provide to the community… it is very much appreciated.
All my best, June N.
To schedule a complimentary PEMF or nutritioinal consultation, Dr. Tamara’s office is (540) 462-7750, and her email is [email protected]. Alternatively, her patient scheduling app is HERE for free consultations or HERE for standard visits.
As long as itu2019s not The $cience(tm), I am all for it.
I appreciate your efforts Robert. Thank you. uD83DuDE4F
As a functional medicine coach, I would suggest looking into selgeline too
My God man, ten *grams* of NAC? Nothing necessarily wrong with it but on my 2400mg NAC daily (capsules) I’m pretty much maxing out what the research literature has studied. But hey, opens my mind.
I will look into glycine. I encourage everyone in the supplement world to remember the possibility of paradoxical effects — GABA for instance induces panic attacks in me. So maybe start smaller than 10 grams but absolutely go by how you feel! Thanks for this post!
download the AI search
best
Ashwagandha has given me panic attacks. DHEA too!
Me as well Some of us turn DHEA into cortisol or catecholamines very quickly and preferentially before aex hormones..
.. epigenetics matter and knowing your individual gene profile is the most helpful information instead of blindly being an experimental guinea pig on yourself and taking therapy instead!
Tried taking NAC during the panicdemic. Think it was 600gm x 2/day, but even one of those made me too nauseas to continue. TEN GMs?!?!
What about Nicotine patches for Parkinsonu2019s? Iu2019ve heard it recommended by several doctors as a bio-hack to ward off neurological disorders like Parkinsonu2019s, Alzheimeru2019s, PAD(peripheral artery disease).I have a family history of all three and I am 71 now. I have tried the 7mg and 14mg patches. I have experienced nightmares and night sweats sometimes from the patches so I stop for a day or two. But the patches do seem to help with muscle stiffness and joint pain especially in the knees and legs, but these are my observations only. I also can be crabby and irritable when wearing them, but the trade off is I feel better physically, including less fatigued. I find that cutting them in half makes them adhere better which is a problem for me because I am outside a lot in hot weather (I live in the tropics) and I sweat a lot. These are just my personal observations about my experiences. I am retired now and travel a lot. I was a realtor before. I like to ski and scuba dive. My goal is to stay active doing these things as long as I can. I have been taking NAC about 3 grams a day split up during the day
and Magnesium Glycinate. Is that considered a form of glycine?
Magnesium Glycinate is an excellent bioavailable form of MG but not a form of glycine
These diseases are not hereditary. Get that out of your mind : )
this is a key insight
Dr. Yoho, have you come across Elliot Overtonu2019s research on thiamine?
will look for it
I think you would appreciate his research and interviews.
I canu2019t find the testimonial video about DMSO helping someoneu2019s eyes that you referred to.
search for DMSO in my archives and “eye” there too
I put CD and DMSO on my eyelids daily. They penetrate to the retina.
A Midwestern Doctor has also written about using DMSO for the eyes:
https://www.midwesterndoctor.com/i/150850494/dmso-and-the-eyes
I queried him about using it with interocular lens (IOL) implants for cataracts, and he u201Cthinksu201D itu2019s okay in very dilute form, like 3%, but heu2019s not sure.
Three of the four types of lens implants u2014 PMMA, hydrophilic acrylic, and hydrophobic acrylic; but not silicone u2014 will react (soften) in DMSO solution, but itu2019s not known if they will react with DMSO after insertion into the cornea. Out of an abundance of caution, I have decided not to put DMSO directly in my eyes, regardless of strength, because of the implants. I use 100% DMSO freely on my skin, however, and have even injected 25% DMSO + lidocaine into a trigger point.
I preserved your comment.
See my summary of AMD’s DMSO material, 100,000 words worth
I use DMSO and CD on my eyelids, and small quantities penetrate to the retina
I have had nothing but a good experience with thiamine. It notably softens and hydrates skin, and helps heal the gut from IBS. I have done thiamine HCl and mononitrate both, same effect. I do it orally and in baths. Have not tried TTFD, will in the future, I have heard good things.
Thiamine HCl is hydrophilic and will harden over time, even in a tight container. Does not seem to affect its action.
After thiamine, the best thing for my gut has been inositol. No more constipation, and it lubricates the rectum. Mmm good! 🙂
thanks for info
I will look into inositol
I’ve been using magnesium oxide for parkinson’s constipation
thiamine is on my must include in supps list
I’ve been taking glycine (~3-4gm) and MSM (~3-4gm) every morning in my coffee for years now w/ a bit of taurine (3-4gm). I cover up the bitterness of the MSM (sulfur) by putting in ~1oz of Irish cream in my coffee. I also take NAC in capsule form — ~800mg/d. No problems at all.
Why are you taking such a large dose of NAC? Just 1200mg/d is a Rx dose for COPD! Sounds a little OD’ish to me as a “supplemental” dose. Is this some Rx protocol? (Retired MD here who came to absolutely despise the for-profit, anti-health allopathic system and so retired at age 59 1/2…when I could get to my SEP-IRA if needed.)
And btw, how much iodine are you taking? I’ve seen such wild numbers from the “alternative” side that I find the recs rather scary. And even scarier is that I’ve seen “evidence ” for low AND high and even VERY high amounts. Makes the findings hard to swallow, pun intended, esp. when some among the alternative medicine crowd warn about OD’ing on iodine.
thanks for writing
the iodine dose is 25-50 (preferably) mg a day. Review why in my recent iodine post
people with glandular cancer may need hundreds of mg a day
and thyroid diseases are individual but often cured with adequate iodine
Do you have glandular cancer? … or thyroid disease? Why such a massive dose? Please provide the studies you or someone else have done showing this is a healthy supplemental dose of iodine … or point me to a website(s). Thanks much. I take ~two drops/wk of 5% Lugols in my coffee = ~12.5mg/wk.
what do you think about eating seaweed instead of taking chemical iodine?
Depends how easy it is to find, how much it costs, how much iodine it supposedly has, and how sure you are that it actually has that iodine content, as well as how sure you are of its lack of contamination with toxic material like mercury.
its find but deciding there is a difference between chemically identical items is irrational
sorry, Y
Don’t know if this response was to me or to @yantra, but I don’t disagree with you, as long as, just to start with, we actually know what exactly the chemical is we’re taking and its purity.
But then again there’s the whole topic of the normal physiologic (ng /mcg) levels of biochemicals found in the healthy body and of multiple related, but minimally different biochemicals / congeners found together in the natural state (in natural foods, especially) in similar nano-and microgram levels as compared to uD835uDDFDuD835uDDF5uD835uDDEEuD835uDDFFuD835uDDFAuD835uDDEEuD835uDDF0uD835uDDFCuD835uDDF9uD835uDDFCuD835uDDF4uD835uDDF6uD835uDDF0uD835uDDEEuD835uDDF9 uD835uDDF1uD835uDDFCuD835uDE00uD835uDDF6uD835uDDFBuD835uDDF4 (mg / gm = 1million ng / 1billion ng, for instance) of only one of the congeners normally found together in nature.
(This is one of the strongest arguments, IMO, for obtaining our nutrients as much as possible from natural, organic foods. And then again there’s the problem of knowing for sure that the “natural foods” we’re going to depend on for our nutrients actually contain them and aren’t contaminated w/toxins we obviously don’t want.)
And of course, we have to read and understand and decide that the studies / experiments we’ve read and are “obeying” are well done, actually prove the value of the dosages we’re taking, and especially that they are relatable to our own situations. Obviously the more desperate our situations, the more we’re going to try to make them fit our own. So at times it can be desperation, not “science,” that’s driving our acceptance of some treatment.
And of course what I just wrote above is just a thumbnail generalization.
read the recent iodine post
read my recent iodine post
“I cover up the bitterness of the MSM (sulfur) by putting in ~1oz of Irish cream in my coffee.”
Ha! u2764uFE0F
I love but can’t afford Irish Cream however: what about filling gel caps with Methylsulfonylmethane or just buying it already encapsulated?
(I recently acquired a hefty little bag of OS (organic suplhur). Ever heard of that stuff doc?)
I’m a curious person: So hat condition (or preconditions) prompted you to begin the glycine and MSM regimen?
FYI, as a bit of background regarding how I began researching health via the internet, around 2001 or so… uD83DuDE09 (Was using books prior to the advent of my introduction to computers and “dial up” on the WWW. Since the early 90’s.)
So… My mother was unable to climb stairs and was in pain. It was something like 25 or more years ago. I suggested she try supplements like MSM with Glucosamine and Chondroitin, as well as a topical cream.
She got better. Felt right as rain… so? She stopped supplementing.
The other day (after walking suddenly became very painful) my brother took her to Urgent Care where a young intern prescribed high dose Tylenol and ordered x-rays.
They just came back: It’s her hips. “Bone on bone.”
Here in Canada, unless a very elderly person falls & breaks one (or both), you’re imeligible for hip replacement surgery.
Not unless they’re FORCED to perform surgery due to breakage…
Mum turns 93 this month but she wouldn’t agree to surgery even if it were “permitted” by our “Health Authorities”.
Her doctor told her all this. Basically said suck it up buttercup.
I’ve recommended topical DMSO for pain (and offered to treat her with my 100% pharmaceutical grade DMSO from Belle Chemical in Montana, which I can highly recommend) & daily supplementation with MSM (which I have in my arsenal too) however since mum is triple jabbed, and suffers with MSM (mainstream media) Acquired Deaf Ears Syndrome, she has declined my offer.
Good luck buttercup. uD83DuDE25
I am going to say an undoubtedly unpopular opinion here.
Drop all the synthetic supplements (none of these are extracts!) and start to eat and live like a human.
You may ask AI what that means 🙂
I often think the same thing. A supplement for this problem, a supplement for this problemu2026 and so on and so on. Take some on an empty stomach, take some with food, donu2019t take this one the same time as that one. What are the excipients, can you get it in pure powder form? How much money am I spending a year on supplements? Anything that has an effect can have a side effect. Some of are not in a position where we can grow our own food or raise our own livestock. We canu2019t control the air we breathe. We can distill our own water to drink. If we live in an apartment, can we attach a filter to our shower head to control the water we bathe in? How about the water we use to wash our clothes, if we live in an apartment? We need to be selective about what, if any, supplements we take. Dr. Yoho, I appreciate the information you share and hope for the best in your managing Parkinsonu2019s. Two of my motheru2019s sisters had Parkinsonu2019s and I have certain nonmototor symptoms commonly found in Parkinsonu2019s that make me wonder if that will be a diagnosis that I will share one day. Best wishes to you.
Aside from the issues of depleted nutrient supplies in soils that would necessitate eating excessive quantities of food/calories to obtain “human” level nutrition, we still have to deal with the very human nature of aging and disease. Nutritional doses will not come close to what’s required for therapeutic treatments.
False on all accounts.
This what the powers-that-should-not-be (and those profiteering from the imaginary consequences aka the supp. sellers) are making you believe (successfully it seems) because they not only control and profit from the pharma poisons, they also control/own and profit from the synthetic supplement junks/poisons.
Good grief uD83DuDE02
Yulia, I suggest you stock up on tinfoil. Thereu2019s a hat in every box.
I’m wearing a hat myself right now
helps with the
emf ha
you have not seen what functional medicine can do
we are dealing with a decline in nutrients much of it purposeful
Yulia:
I am admittedly no expert, but what has slowly percolated through my thick head over the past few years is the power of targeted supplements to replace the entirety of conventional medical care.
This is a key point and I pinned it to the top of the comments.
Something to think about. Yep.
https://nanostructuresinus.substack.com/p/ribbons-and-filaments-in-blood-whats
(This stack pertains to: Morgellons victim research.)
“Withdrawing GlyNAC for 12 weeks results in a loss or decrease in benefits”.
Is there some exact data on this? Is it just back to baseline? Or does it cause a reflexive drop? Compensatory mechanism?
Also have look at the effects of light on the substansia niger. That’s supposed to be melanin sheets in there. Parkinsons is a direct long-term result of circadian dysregulation and blue light toxicity.
But don’t listen to me, go plug it in to pubmed, etc. yourself and have a look. I’ve got skin in the game too, so there is zero motivation to waste your precious time with BS.uD83DuDE09
I always respect what you say.
PD’s causation is obscure, and flatfootedly saying that circadian dysruption is causal is a step too far. Mercury alone plays a lion’s share, and the gut microbiome is heavily implicated. But WTF am I sure about after studying it for years? Surprisingly, not much.
Not sure where it came from, but my sources are exhaustive. I’m too exhausted with this to search them for you, ha…
I haven’t finished reading this yet but the first thing that came to me was your liver. The acupuncturist that I see says tremors get in through the liver… maybe you already know this. So getting off all supplements is a good idea! You have encouraged me (by your self experimentation) to wean myself off the few meds I was taking (including thyroid – which I think is over diagnosed!) and I am now on ZERO! I feel fine.
I was just able to skim over this, but I’m very interested in taking a deep dive later. I’ve been taking NAC and glycine (in my whey protein) at 1.2gms/day. My only concern was that NAC disrupts biofilms, which is good for pathogenic biofilms, but we have necessary biofilms as well. I didn’t know where I should draw the line (if at all), so I did a brief search. I still haven’t resolved the question of whether I should take it consistently or occasionally, but I did come across this from Chris Masterjohn, answering a question about using NAC to disrupt biofilms:
“N-acetylcysteine or NAC can be used at a dose of 600 to 2,400 milligrams per day for 5-10 days to disrupt biofilms and make it easier for antimicrobials to kill bacteria. Animal studies suggest that acute doses up to 6 grams do not deplete mucus or cause ulceration, but that an acute dose of 17.5 grams can deplete mucus and cause ulcers within two hours. Human studies suggest that 10 grams per day can be used for 24 weeks with fewer than 1 in 6 people complaining of gastrointestinal side effects. Yet, chronic use of NAC will thin the mucus, disrupt the biofilms used by normal healthy microbiota, and possibly deliver excessive sulfur to certain components of the microbiome. Therefore, I would not use it except for specific, targeted reasons, and I would not use it at a dose higher than needed or for a duration longer than needed.”
You obviously have a specific, targeted reason. It may be useful to keep this in mind for any future GI side effects as it’s hard to pin down these sorts of problems when they occur. One thing to consider might be cycling it?
I am a big fan of Chris Masterjohn. I take NAC but not daily. Chris also talks about how NAC affects methylation, and recommends you take it with Methylfolate and TMG (trimethylglycine), which I do.
I also take liposomal glutathione (also not daily), which is a form the body can use.
I take collagen nearly every day. Love it.
Thanks for that. I saw him talk about that issue with nicotinic acid, but I wasn’t aware that it’s also an issue with NAC. With nicotinic acid, he said that there’s a sort of “threshold” amount where he sees it as a problem, something over a gram I believe. I’m wondering if it’s the same with NAC.
great idea and your use of whey protein may be what I am looking for to improve tolerability
great idea to freaking cycle everything
As always Dr. Yoho I look forward to your episodes and appreciate your perspective.
However I do not believe Giorgi Dinkov (Haidut) is either “brilliant” or his website is a source for well thought out nutrition advice. He constantly uses small rodent studies to make huge, unsupported claims.
His latest article “Low-carb diet and chronic (even mild) stress sufficient to cause heart disease (CVD) and depression” is based on a rat study and his own experience going low carb for a short time in 2008 and realizing it was “detrimental to his health.” I do not believe the “evidence” he cites and a N=1 is convincing.
This goes for B1 TTFD as well. The basis for this was a study of 6 rats. He also publishes literally a dozen articles on one day (Sept. 16) and does that multiple days and times. I do not know anyone else who can do that volume of research thoughtfully and responsibly.
I have no issue with people who want to follow Ray Peat or for that matter any dietary strategy. My problem is that he makes ridiculous claims using rodent, limited scope trials.
It appears to me that his main intention is to sell his supplements (IdeaLabs LLC), which on his website he says are ” customized, liquid COSMETIC products based on the ideas of metabolic/energetic theory of health.”
Thanks for the thoughtful heads-up.
Love this, and your study of it is 100 x deeper than mine. I will not buy any more TTFD. I pinned it to the top of the comments.
radar phos
9:32u202FAM (4 minutes ago)
to MD
Dr. Yoho;
I’m a paid subscriber. I have a question about DMSO that you mentioned in your article, along with NAC (that has an odor) along with Glycine. I just got off another week with near 2 tsp DMSO in 7 oz water each time for a week. I rarely smell an odor; but my wife despisingly-hates the odor. But I also take NAC at least 1/day if not 2/day. Now I am wondering if the DMSO may be reacting with the NAC’s odor (in my body) causing a bad exhalation odor. What I think I know is that DMSO’s sulphur content is enough to do that on its own, but possibly the NAC (I take Mercola’s capsul NAC) is worsening it, if not also causing it. My question is whether it is likely that the NAC is worsening the odor, if not causing it. Do you have an opinion? If you are taking both (all three) do you get comments from anyone you are around? I tend to avoid DMSO 24 hrs before knowing I will be around people. Do you do that also? Though I asked many questions, what I’m really wondering about is if the NAC that I take is worsening the DMSO odor?
It sounds like you have a sulfur detox/ metabolism issue and this can be triggered but goods and supplements, meds high in sulfur. Overloading your bucket of sulfur can overwhelm your bodies ability to process it if you have any genetic SNPs that can’t handle it well.. and it can trigger histamine issues as well. What works for ONE person does not always work for another. If you feel awful, your body is telling you something!!
i don’t take nac, glycine or any other sulfur containing supplements. but just using TINY amounts of dmso, like on a toe, causes a delicate sulfur fragrance to waft from my body and at times i even smell it on my clothes. it smells very much like i smell when i cook with tiny amounts of hing (asafoetida), a very unusually fragrant and sulfurous indian spice.
MSM supposedly does the same thing as DMSO, and without the smell, but I have not evaluated it yet. Stay tuned for a few weeks. My wife tolerates my smell, and I’m antisocial enough that I care little about others, ha. As Gore Vidal said, he was interested in what he thought of others rather than what others thought of him. 2 tsp is a tiny dose of DMSO; I’m on 2 tablespoons a day now. Not sure about Mercola’s NAC and the dose you are taking is low of this too. Best
I have been taking Magnesium Glycinate drops with Tart Cherry extract. I have been taking NAC for years.
I’ve missed NAC until now
According to Dr. Dietrich Klinghardt, u201Cglyphosate is an analog of the amino acid glycine. It attaches in the body in places where we actually need glycine. If you take 4 grams (a level teaspoon) twice a day, you will see that immediately the glyphosate in the urine goes up. Thatu2019s what we want. We try to saturate the system with glycine. We want the glyphosate in the urine. You donu2019t want it in your brain. In the U.S., even organic food has 80 percent of the same glyphosate content as non-organic food. It [glyphosate] rains down on us.u201D
love it
After this brief review, glycine seems harmless.
chlorine dioxide also destroys glyphosate
I was going to ask you if you had heard of high dose thiamine. Thiamine and Benfotiamine can both be obtained cheaply in a powder form. It can be mixed in a little water or fruit juice and drank. It sure doesn’t taste great, but it’s not the end of the world bad either. Might be worth a try. At worst you’ll be out $20.
I’ve got it but was fooled by the TTFD thing. Thanks, Agent! (the good agent)
As soon as I read the title, I thought ” good Lord this would kill me! “But glad it’s helping YOU and your Parkinson’s..
I’ve posted before and remember I’m a big advocate for epigenetic testing and knowing what your own DNA, mitochondria, cells and biochemical pathways are going to do with the supplements … just like any medication. We are all unique individuals and what works for one does not work for all !
NAC and glutathione can be very problematic for people with transsulfuration pathway issues and genetic SNPs In sulfur processing.. often you can tell by being people that “sulfur sensitive “.
Overloading this system can create horrible side effects, including histamine release and all related sulfur and histamine related issues.. severe anxiety, G.I. Or cardiac symptoms, allergic like reactions.
And at that mega mega dose, it would probably take some of us out and into heaven, so yes, we would definitely be cured lol !!
However, for others, NAC including glutathione is like magic to their cells, (NAC is the precursor to glutathione) The master antioxidant!
So as I always say :
test don’t guess, it’s best to know your epigenetic’s unless you want to be a personal human guinea pig and figure this out by trial and error, rolling the dice and spending all kinds of money on supplements that can become very expensive .
What works for ONE doesn’t work for ALL and like homeopathy, the dose can also be the poison.
And I must conclude by saying “I am not an anomaly” as Robert likes too often to rebut .
-issues with transulfuration and these pathways are common
A really good book along this vein in Dr. Neil Nathan’s “Toxic.” Biochemical individuality is real and obvious, and so is the fact that toxins abound in today’s world and we don’t drink enough pure water or eat enough good food to handle them.
I drank fluoridated tapwater my whole life. Jeez
Let’s get together, and you can discuss these issues on a podcast via Zoom. The conventional literature I read about GlyNAC–and it is substantial–suggested that reactions to it were anomalous. I will try to call within a week, but I am slammed.
Forgot to mention that since the substantial Niagra , (which is responsible for Parkinson’s), is strongly influenced by light because of its melanin, taking a deep dive into light exposure, and exact types of wavelengths of light is probably going to be the biggest bang for your buck on this quest.
Jack Kruse is a personal favorite but lots of other research into altering melanin with light therapies.
IMHO, Jack’s favorite issues, light and EMF, are minor league for most people compared with vaccinations and the unbelievably damaging panoply of other adverse medical care. And his personal style is pretentious and intolerable. So I ignore him, sorry.
Where can you buy GlyNAC?
Is it ok to load your own caps if order the NAC powder? I mean will it still absorb and mix with the Glycine? Or load both and take at same time maybe so caps dissolve together at same time?
Excellent report thanks for the effort and for sharing information. Do you know if taking magnesium glycinate provides a source of glycine in addition to mg? Thanks
I think it is different
Iu2019ve just ordered some of both and will give this a shot
You guys need to consider that some supplements are poison. If you don’t trust anyone else, (myself included) how can you trust them?
we are all on a learning curve
Hi Dr. Yoho: I have fibromyalgia. I am 71. Would GlyNAC help the inflammation in my body?
What Brand? What dosage? Please Reply….Thank YOU 🙂
my sophistication is intermediate, so look at the sources. Consider hormone supplementation as well. Read Hormone Secrets.
Greetings! Dr. Robert, thank you! Came across you possibly because your mention of NAC. I have been taking Swanson Vitamins’ NAC 600 mg. since 2009. I have not had any flu, Coronavirus’ and maybe one cold since then. HA! I did not even know that it has an awful taste. It’s now about $10.00 a bottle. Child: 1/Day Adult: 2/Day I take one with a meal and one before sleep. They now have 1000 mg. capsules. I now take only one of these daily before sleep. My husband had Parkinson’s for fifteen years living until 89. He only took natural meds no drugs. Piracetam (used to be a drug) was helpful. He did very well (very little shaking) until his last year when he was bedridden. He was two days in the hospital then two days in hospice. In his last few months he had visual delusions which I later learned happens with Parkinson’s patients. This also occurs with the body is shutting down. We registered with Science Care donating our bodies when dead. They were very nice handled him well, some ashes were returned, a tree planted in his name, and not costing me 1 cent! uD83DuDE32 THIS was very helpful! I post publicly on MeWe. Maybe I will order glycine capsules. I do take Swanson’s Lysine capsules, another amino acid.
great source and ideas and I appreciate the encouragement and sources. I pinned your comment to the top and preserved it. Best
Hello,
I havenu2019t been getting your stuff that long, so please forgive me if this is something you already know or have covered. I assume you know about mucuna prurins for Parkinsonu2019s. If you do not, please do yourself a favor and research it. Every person, that I know of, that has Parkinsonu2019s and is also taking the mucuna, is almost totally back to a normal life and feeling normal. No tremors, no dyskinesia etc. my dad is 81 and has been taking it for a year is doing great!! If you want more information I will gladly give it to you.